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Title of Journal: Inflamm Bowel Dis

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Abbravation: Inflammatory Bowel Diseases

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Narnia

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DOI

10.1002/chin.198825247

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1078-0998

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Comparative analysis of colonic gene expression of

Authors: te Velde Anje A de Kort Floor Sterrenburg Ellen Pronk Inge ten Kate Fiebo JW Hommes Daniel W van Deventer Sander JH
Publish Date: 2007/03/01
Volume: 13, Issue: 3, Pages: 325-330
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Abstract

Anje A te Velde Floor de Kort Ellen Sterrenburg Inge Pronk Fiebo JW ten Kate Daniel W Hommes Sander JH van Deventer Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease Inflammatory Bowel Diseases Volume 13 Issue 3 1 March 2007 Pages 325–330 https//doiorg/101002/ibd20079Using Agilent mouse TOX oligonucleotide microarrays we analyzed colonic gene expression profiles in three widely used models of experimental colitis In 2 of the models TNBS and DSSinduced colitis exogenous agents induce the colitis In the third model the colitis is induced after transfer of a Tcell population CD4+CD45RBhigh T cells that lacks regulatory cells into an immunodeficient hostCompared with control mice in DSS TNBS and the CD45RB transfer colitis mice 387 21 and 582 genes were more than 2fold upregulated in the intestinal mucosa Analyses of exclusively shared gene expression profiles between the different models revealed that DSS/transfer colitis share 69 concordantly upregulated genes DSS/TNBS 6 and TNBS/transfer colitis 1 Seven genes were upregulated in all three models The CD45RB transfer model expression profile included the most genes that are known to be upregulated in IBD Of 32 genes that are known to change transcriptional activity in IBD TNF IFNγ Ltβ IL6 IL16 IL18R1 IL22 CCR2 7 CCL2 3 4 5 7 11 17 20 CXCR3 CXCL1 5 10 Mmp3 79 14 Timp1 Reg3γ and Pap S100a8 S100a9 Abcb1 and Ptgs2 2/32 are upregulated in TNBS 15/32 are upregulated or downregulated in DSS and 30/32 are upregulated or downregulated in the CD45RB transfer colitis


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  1. Gender and Location of CRC in IBDImplications for Surveillance Protocols
  2. Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent
  3. Targeting TNF in Postoperative Recurrence of Crohn's Disease:Can We Extinguish the Fire Before It Starts?
  4. Gene Expression Profiling Identifies Mechanisms of Protection to Recurrent Trinitrobenzene Sulfonic Acid Colitis Mediated by Probiotics
  5. Adalimumab Therapy in Crohn's Disease of the Ileal Pouch
  6. Observations on Severity and Activity Indices in a Therapeutic Trial of Active Crohn's Disease
  7. Splenic function and IgM-memory B cells in Crohn's disease patients treated with infliximab
  8. One-year Investigator-blind Randomized Multicenter Trial Comparing Asacol 2.4 g Once Daily with 800 mg Three Times Daily for Maintenance of Remission in Ulcerative Colitis
  9. Role of diet in the development of inflammatory bowel disease
  10. Thromboembolism in pediatric inflammatory bowel disease: Systematic review
  11. Potential Oncogenic Properties of Mobilized Stem Cells in a Subpopulation of Inflammatory Bowel Disease Patients Infected with Helicobacter pylori
  12. Potential Oncogenic Properties of Mobilized Stem Cells in a Subpopulation of Inflammatory Bowel Disease Patients Infected with Helicobacter pylori
  13. Twin Studies Reveal Specific Imbalances in the Mucosaassociated Microbiota of Patients with Ileal Crohn's Disease
  14. Microbial Causation of the Chronic Idiopathic Inflammatory Bowel Diseases
  15. Babesiosis in a Patient on Infliximab for Crohn's Disease
  16. Plasma Chromogranin A in Patients With Inflammatory Bowel Disease: A Possible Explanation
  17. Effect of Adalimumab on Clinical Laboratory Parameters in Patients with Crohn's Disease: Results from the CHARM Trial
  18. Natural history of bone metabolism and bone mineral density in children with inflammatory bowel disease
  19. What is the incidence, prevalence, and natural history of indeterminate colitis?
  20. Anti-tumor Necrosis Factor and Postoperative Complications in Crohn's Disease: Systematic Review and Meta-analysis
  21. Effects of T cell-induced colonic inflammation on epithelial barrier function†
  22. Seroreactivity to microbial components in Crohn's disease is associated with ileal involvement, noninflammatory disease behavior and NOD2/CARD15 genotype, but not with risk for surgery in a Hungarian cohort of IBD patients
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  24. Dangers associated with endoscopic management of strictures in IBD
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  29. Distinct Microbiome in Pouchitis Compared to Healthy Pouches in Ulcerative Colitis and Familial Adenomatous Polyposis
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