Authors: Daniel Fady Loriot MarieAnne Seksik Philippe Cosnes Jacques Gornet JeanMarc Lémann Marc Fein Francine VernierMassouille Gwenola De Vos Martine Boureille Arnaud Treton Xavier Flourié Bernard Roblin Xavier Louis Edouard Zerbib Frank Beaune Philippe Marteau Philippe
Publish Date: 2007/01/01
Volume: 13, Issue: 1, Pages: 19-23
Abstract
Fady Daniel MarieAnne Loriot Philippe Seksik Jacques Cosnes JeanMarc Gornet Marc Lémann Francine Fein Gwenola VernierMassouille Martine De Vos Arnaud Boureille Xavier Treton Bernard Flourié Xavier Roblin Edouard Louis Frank Zerbib Philippe Beaune Philippe Marteau Multidrug resistance gene1 polymorphisms and resistance to cyclosporine a in patients with steroid resistant ulcerative colitis Inflammatory Bowel Diseases Volume 13 Issue 1 1 January 2007 Pages 19–23 https//doiorg/101002/ibd20046Cyclosporine A CsA is inconstantly effective in inducing remission in acute attacks of ulcerative colitis UC not responding to steroids This study aimed to establish whether multidrug resistance gene MDR1 polymorphisms would be associated with CsA failureThe distribution of the different genotypes of single nucleotide polymorphisms SNP G2677T/A and C3435T of MDR1 exons 21 and 26 respectively was studied in 154 patients mean age 44 yr who had received CsA to treat severe attacks of steroid resistant UC in 11 centers in France and Belgium Patients were classified as CsA failure n = 50 when they needed colectomy within 30 days after CsA initiation The SNPs were detected by use of a 5′ nuclease allelic discrimination assayThere was a significant association between the G2677T/A polymorphism distribution exon 21 and the risk for CsA failure P = 00001 The TT genotype of exon 21 was significantly associated with the risk compared with the two other genotypes odds ratio 377 95 confidence interval 142–997 P = 0007 There was no significant association between the genotype C3435T distribution exon 26 and the risk of CsA failure P = 023The TT genotype of exon 21 MDR1 polymorphisms is associated with a higher risk of CsA failure in patients with steroid resistant UC Further studies should be performed to establish whether other treatments could be more efficient to avoid surgery in this subset of patients
Keywords: