Authors: Lazzerini Marzia Bramuzzo Matteo Maschio Massimo Martelossi Stefano Ventura Alessandro
Publish Date: 2011/10/01
Volume: 17, Issue: 10, Pages: 2174-2183
Abstract
Marzia Lazzerini Matteo Bramuzzo Massimo Maschio Stefano Martelossi Alessandro Ventura Thromboembolism in pediatric inflammatory bowel disease Systematic review Inflammatory Bowel Diseases Volume 17 Issue 10 1 October 2011 Pages 2174–2183 https//doiorg/101002/ibd21563Several studies suggest an increased risk of venous and arterial thromboembolism TE in adults with inflammatory bowel disease IBD compared to the general population We performed a systematic review of studies on incidence and characteristic of TE in children with IBDPopulation studies suggest that there is an increased risk of TE in children with IBD compared to controls TE occurred in children with IBD in all age ranges mostly 828 during active disease and more frequently in children with ulcerative colitis odds ratio OR 37 95 confidence interval CI 18–76 At least one specific risk factor for TE was recognized in 50 of cases two risk factors were present in 24 Out of 92 published cases of TE in children with IBD 543 occurred in cerebral site 26 in the limbs 13 in the abdominal vessels and the remaining in the retina and lungs After a first episode of TE an early recurrence was observed in 114 of children a late recurrence in 10 A number of different therapeutic schemes were used Overall mortality was 57 and was mostly associated with cerebral TE
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