Authors: Koutroubakis Ioannis E Karmiris Konstantinos Bourikas Leonidas Kouroumalis Elias A Drygiannakis Ioannis Drygiannakis Dimitrios
Publish Date: 2007/04/01
Volume: 13, Issue: 4, Pages: 504-505
Abstract
Ioannis E Koutroubakis Konstantinos Karmiris Leonidas Bourikas Elias A Kouroumalis Ioannis Drygiannakis Dimitrios Drygiannakis Antibodies Against Cyclic Citrullinated Peptide CCP in Inflammatory Bowel Disease Patients With or Without Arthritic Manifestations Inflammatory Bowel Diseases Volume 13 Issue 4 1 April 2007 Pages 504–505 https//doiorg/101002/ibd20038Inflammatory bowel disease IBD is commonly associated with arthritic manifestations such as inflammatory peripheral arthropathy and axial involvement including sacroiliitis and spondylitis1 Articular involvement peripheral or axial can precede be synchronous to or begin after the diagnosis of IBDAntibodies recognizing cyclic citrullinated peptides antiCCP are directed to proteins that contain the unusual amino acid citrulline which is derived from the posttranslational modification of arginine by peptidylarginine deiminases These antibodies are highly specific for rheumatoid arthritis RA2 and it has been demonstrated that they contribute to the perpetuation of joint inflammation3 The role of antiCCP in IBD and especially in IBD patients with arthritic manifestations remains unclear The aim of our study was to evaluate the prevalence and clinical associations of antiCCP antibodies in IBD patients with and without arthritic manifestations
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