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Title of Journal: Inflamm Bowel Dis

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Abbravation: Inflammatory Bowel Diseases

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Narnia

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1078-0998

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Twin Studies Reveal Specific Imbalances in the Muc

Authors: Willing Ben Halfvarson Jonas Dicksved Johan Rosenquist Magnus Järnerot Gunnar Engstrand Lars Tysk Curt Jansson Janet K
Publish Date: 2009/05/01
Volume: 15, Issue: 5, Pages: 653-660
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Abstract

Ben Willing Jonas Halfvarson Johan Dicksved Magnus Rosenquist Gunnar Järnerot Lars Engstrand Curt Tysk Janet K Jansson Twin Studies Reveal Specific Imbalances in the Mucosaassociated Microbiota of Patients with Ileal Crohns Disease Inflammatory Bowel Diseases Volume 15 Issue 5 1 May 2009 Pages 653–660 https//doiorg/101002/ibd20783To reduce variations in exposure during establishment of the gut flora and the influence of genotype we studied the mucosaassociated microbiota of monozygotic twin pairs that were discordant n = 6 or concordant n = 4 for CD DNA was extracted from biopsies collected from 5 locations between the ileum and rectum Bacterial 16S ribosomal RNA genes were amplified and community composition assessed by terminalrestriction fragment length polymorphism cloning and sequencing and quantitative realtime polymerase chain reaction PCRThe microbial compositions at all biopsy locations for each individual were similar regardless of disease state but there were differences between individuals In particular individuals with predominantly ileal CD had a dramatically lower abundance P 0001 of Faecalibacterium prausnitzii and increased abundance P 003 of Escherichia coli compared to healthy cotwins and those with CD localized in the colon This dysbiosis was significantly correlated to the disease phenotype rather than genotypeThe reduced abundance of F prausnitzii and increased abundance of E coli are indicative of an ileal CD phenotype distinct from colonic CD and the relative abundances of these specific bacterial populations are promising biomarker candidates for differential diagnosis of CD and eventually customized treatment


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References

citation journal title=Gastroenterology citation year=2000 citation volume=119 citation pages=17401744


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  1. Gender and Location of CRC in IBDImplications for Surveillance Protocols
  2. Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent
  3. Targeting TNF in Postoperative Recurrence of Crohn's Disease:Can We Extinguish the Fire Before It Starts?
  4. Gene Expression Profiling Identifies Mechanisms of Protection to Recurrent Trinitrobenzene Sulfonic Acid Colitis Mediated by Probiotics
  5. Adalimumab Therapy in Crohn's Disease of the Ileal Pouch
  6. Observations on Severity and Activity Indices in a Therapeutic Trial of Active Crohn's Disease
  7. Splenic function and IgM-memory B cells in Crohn's disease patients treated with infliximab
  8. One-year Investigator-blind Randomized Multicenter Trial Comparing Asacol 2.4 g Once Daily with 800 mg Three Times Daily for Maintenance of Remission in Ulcerative Colitis
  9. Role of diet in the development of inflammatory bowel disease
  10. Thromboembolism in pediatric inflammatory bowel disease: Systematic review
  11. Potential Oncogenic Properties of Mobilized Stem Cells in a Subpopulation of Inflammatory Bowel Disease Patients Infected with Helicobacter pylori
  12. Potential Oncogenic Properties of Mobilized Stem Cells in a Subpopulation of Inflammatory Bowel Disease Patients Infected with Helicobacter pylori
  13. Microbial Causation of the Chronic Idiopathic Inflammatory Bowel Diseases
  14. Babesiosis in a Patient on Infliximab for Crohn's Disease
  15. Plasma Chromogranin A in Patients With Inflammatory Bowel Disease: A Possible Explanation
  16. Effect of Adalimumab on Clinical Laboratory Parameters in Patients with Crohn's Disease: Results from the CHARM Trial
  17. Natural history of bone metabolism and bone mineral density in children with inflammatory bowel disease
  18. What is the incidence, prevalence, and natural history of indeterminate colitis?
  19. Anti-tumor Necrosis Factor and Postoperative Complications in Crohn's Disease: Systematic Review and Meta-analysis
  20. Effects of T cell-induced colonic inflammation on epithelial barrier function†
  21. Seroreactivity to microbial components in Crohn's disease is associated with ileal involvement, noninflammatory disease behavior and NOD2/CARD15 genotype, but not with risk for surgery in a Hungarian cohort of IBD patients
  22. Multidrug resistance gene-1 polymorphisms and resistance to cyclosporine a in patients with steroid resistant ulcerative colitis
  23. Dangers associated with endoscopic management of strictures in IBD
  24. Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease†
  25. Role of the interleukin 24 in patients with ulcerative colitis
  26. Antibodies Against Cyclic Citrullinated Peptide (CCP) in Inflammatory Bowel Disease Patients With or Without Arthritic Manifestations
  27. Nitric Oxide and Colitis: Rats, Humans and Now Macaques
  28. Distinct Microbiome in Pouchitis Compared to Healthy Pouches in Ulcerative Colitis and Familial Adenomatous Polyposis
  29. Is Crohn's creeping fat an adipose tissue?
  30. Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease
  31. Cyclosporine in the management of severe ulcerative colitis while breast-feeding
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  33. Local Injection of Infliximab in Symptomatic Isolated Mucosal LesionsA Novel Scenario for Endoscopic Therapy?
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