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Title of Journal: Inflamm Bowel Dis

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Abbravation: Inflammatory Bowel Diseases

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Narnia

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DOI

10.1007/s003399900218

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ISSN

1078-0998

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Protective effects of dietary curcumin in mouse mo

Authors: BillereyLarmonier Claire Uno Jennifer K Larmonier Nicolas Midura Anna J Timmermann Barbara Ghishan Fayez K Kiela Pawel R
Publish Date: 2008/06/01
Volume: 14, Issue: 6, Pages: 780-793
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Abstract

Claire BillereyLarmonier Jennifer K Uno Nicolas Larmonier Anna J Midura Barbara Timmermann Fayez K Ghishan Pawel R Kiela Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent Inflammatory Bowel Diseases Volume 14 Issue 6 1 June 2008 Pages 780–793 https//doiorg/101002/ibd20348Curcumin diferulolylmethane has been shown to have a protective role in mouse models of inflammatory bowel diseases IBD and to reduce the relapse rate in human ulcerative colitis UC thus making it a potentially viable supportive treatment option Trinitrobenzene sulfonic acid TNBS colitis in NKTdeficient SJL/J mice has been described as Th1mediated inflammation whereas BALB/c mice are believed to exhibit a mixed Th1/Th2 responseIn the BALB/c mice curcumin significantly increased survival prevented weight loss and normalized disease activity In the SJL/J mice curcumin demonstrated no protective effects Genomewide microarray analysis of colonic gene expression was employed to define the differential effect of curcumin in these 2 strains This analysis not only confirmed the disparate responses of the 2 strains to curcumin but also indicated different responses to TNBS Curcumin inhibited proliferation of splenocytes from naive BALB/c mice but not SJL/J mice when nonspecifically stimulated in vitro with concanavalin A ConA Proliferation of CD4+ splenocytes was inhibited in both strains albeit with about a 2fold higher IC50 in SJL/J mice Secretion of IL4 and IL5 by CD4+ lymphocytes of BALB/c mice but not SJL/J mice was significantly augmented by ConA and reduced to control levels by curcuminThe efficacy of dietary curcumin in TNBS colitis varies in BALB/c and SJL/J mouse strains Although the exact mechanism underlying these differences is unclear the results suggest that the therapeutic value of dietary curcumin may differ depending on the nature of immune dysregulation in IBD

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References

citation journal title=Gastroenterology citation year=2007 citation volume=133 citation pages=11881197

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  1. Gender and Location of CRC in IBDImplications for Surveillance Protocols
  2. Targeting TNF in Postoperative Recurrence of Crohn's Disease:Can We Extinguish the Fire Before It Starts?
  3. Gene Expression Profiling Identifies Mechanisms of Protection to Recurrent Trinitrobenzene Sulfonic Acid Colitis Mediated by Probiotics
  4. Adalimumab Therapy in Crohn's Disease of the Ileal Pouch
  5. Observations on Severity and Activity Indices in a Therapeutic Trial of Active Crohn's Disease
  6. Splenic function and IgM-memory B cells in Crohn's disease patients treated with infliximab
  7. One-year Investigator-blind Randomized Multicenter Trial Comparing Asacol 2.4 g Once Daily with 800 mg Three Times Daily for Maintenance of Remission in Ulcerative Colitis
  8. Role of diet in the development of inflammatory bowel disease
  9. Thromboembolism in pediatric inflammatory bowel disease: Systematic review
  10. Potential Oncogenic Properties of Mobilized Stem Cells in a Subpopulation of Inflammatory Bowel Disease Patients Infected with Helicobacter pylori
  11. Potential Oncogenic Properties of Mobilized Stem Cells in a Subpopulation of Inflammatory Bowel Disease Patients Infected with Helicobacter pylori
  12. Twin Studies Reveal Specific Imbalances in the Mucosaassociated Microbiota of Patients with Ileal Crohn's Disease
  13. Microbial Causation of the Chronic Idiopathic Inflammatory Bowel Diseases
  14. Babesiosis in a Patient on Infliximab for Crohn's Disease
  15. Plasma Chromogranin A in Patients With Inflammatory Bowel Disease: A Possible Explanation
  16. Effect of Adalimumab on Clinical Laboratory Parameters in Patients with Crohn's Disease: Results from the CHARM Trial
  17. Natural history of bone metabolism and bone mineral density in children with inflammatory bowel disease
  18. What is the incidence, prevalence, and natural history of indeterminate colitis?
  19. Anti-tumor Necrosis Factor and Postoperative Complications in Crohn's Disease: Systematic Review and Meta-analysis
  20. Effects of T cell-induced colonic inflammation on epithelial barrier function†
  21. Seroreactivity to microbial components in Crohn's disease is associated with ileal involvement, noninflammatory disease behavior and NOD2/CARD15 genotype, but not with risk for surgery in a Hungarian cohort of IBD patients
  22. Multidrug resistance gene-1 polymorphisms and resistance to cyclosporine a in patients with steroid resistant ulcerative colitis
  23. Dangers associated with endoscopic management of strictures in IBD
  24. Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease†
  25. Role of the interleukin 24 in patients with ulcerative colitis
  26. Antibodies Against Cyclic Citrullinated Peptide (CCP) in Inflammatory Bowel Disease Patients With or Without Arthritic Manifestations
  27. Nitric Oxide and Colitis: Rats, Humans and Now Macaques
  28. Distinct Microbiome in Pouchitis Compared to Healthy Pouches in Ulcerative Colitis and Familial Adenomatous Polyposis
  29. Is Crohn's creeping fat an adipose tissue?
  30. Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease
  31. Cyclosporine in the management of severe ulcerative colitis while breast-feeding
  32. Nailing down the shingles in IBD
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