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Title of Journal: Inflamm Bowel Dis

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Abbravation: Inflammatory Bowel Diseases

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Narnia

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DOI

10.1016/0039-6028(79)90504-1

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ISSN

1078-0998

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Combination of innate and adaptive immune alterati

Authors: Ippoliti Andrew Devlin Shane Mei Ling Yang Huiying Papadakis Konstantinos A Vasiliauskas Eric A McGovern Dermot PB Abreu Maria T Melmed Gil Shaye Omid Enayati Pedram Chen Gary Choi Jennifer Taylor Kent Landers Carol J Rotter Jerome I Targan Stephan R
Publish Date: 2010/08/01
Volume: 16, Issue: 8, Pages: 1279-1285
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Abstract

Andrew Ippoliti Shane Devlin Ling Mei Huiying Yang Konstantinos A Papadakis Eric A Vasiliauskas Dermot PB McGovern Maria T Abreu Gil Melmed Omid Shaye Pedram Enayati Gary Chen Jennifer Choi Kent Taylor Carol J Landers Jerome I Rotter Stephan R Targan Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohns disease† Inflammatory Bowel Diseases Volume 16 Issue 8 1 August 2010 Pages 1279–1285 https//doiorg/101002/ibd21196Mutations in the nucleotide oligomerization domain2 NOD2 gene and positive antibodies to microbial antigens have been found to be associated with the Crohns disease CD phenotype fibrostenosis The aim of this study was to confirm these relationships in a large cohort of CD patients and to determine the correlation between the presence of NOD2 variants and antibodies to oligomannan CBir outer membrane porinC OmpC and I2 in CD patients with fibrostenosisSera and DNA from 731 unrelated CD patients were tested for NOD2 variants SNP 8 12 and 13 and the antibodies The results were correlated with CD phenotypes fibrostenosis internal penetrating perianal penetrating and ulcerative colitis UClike as well as other clinical featuresThe presence of NOD2 allelic variants was primarily associated with fibrostenosis secondarily with small bowel disease and small bowel surgery and was inversely associated with UClike disease This association was present in patients with a fibrostenosis only Vienna B2 and those with both stricturing and penetrating disease The presence and level of antibodies to microbial antigens was also associated with the fibrostenosis phenotype In the 316 patients with fibrostenosis the prevalence of NOD2 variants was significantly correlated with the antibody titer by quartile sum score Further when these patients with fibrostenosis were clustered by quartile sum score the odds ratio for fibrostenosis was significantly higher in the patients with NOD2 variant alleles within each cluster indicating synergy


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References

citation journal title=Gastroenterology citation year=2006 citation volume=131 citation pages=366378


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Other Papers In This Journal:

  1. Gender and Location of CRC in IBDImplications for Surveillance Protocols
  2. Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent
  3. Targeting TNF in Postoperative Recurrence of Crohn's Disease:Can We Extinguish the Fire Before It Starts?
  4. Gene Expression Profiling Identifies Mechanisms of Protection to Recurrent Trinitrobenzene Sulfonic Acid Colitis Mediated by Probiotics
  5. Adalimumab Therapy in Crohn's Disease of the Ileal Pouch
  6. Observations on Severity and Activity Indices in a Therapeutic Trial of Active Crohn's Disease
  7. Splenic function and IgM-memory B cells in Crohn's disease patients treated with infliximab
  8. One-year Investigator-blind Randomized Multicenter Trial Comparing Asacol 2.4 g Once Daily with 800 mg Three Times Daily for Maintenance of Remission in Ulcerative Colitis
  9. Role of diet in the development of inflammatory bowel disease
  10. Thromboembolism in pediatric inflammatory bowel disease: Systematic review
  11. Potential Oncogenic Properties of Mobilized Stem Cells in a Subpopulation of Inflammatory Bowel Disease Patients Infected with Helicobacter pylori
  12. Potential Oncogenic Properties of Mobilized Stem Cells in a Subpopulation of Inflammatory Bowel Disease Patients Infected with Helicobacter pylori
  13. Twin Studies Reveal Specific Imbalances in the Mucosaassociated Microbiota of Patients with Ileal Crohn's Disease
  14. Microbial Causation of the Chronic Idiopathic Inflammatory Bowel Diseases
  15. Babesiosis in a Patient on Infliximab for Crohn's Disease
  16. Plasma Chromogranin A in Patients With Inflammatory Bowel Disease: A Possible Explanation
  17. Effect of Adalimumab on Clinical Laboratory Parameters in Patients with Crohn's Disease: Results from the CHARM Trial
  18. Natural history of bone metabolism and bone mineral density in children with inflammatory bowel disease
  19. What is the incidence, prevalence, and natural history of indeterminate colitis?
  20. Anti-tumor Necrosis Factor and Postoperative Complications in Crohn's Disease: Systematic Review and Meta-analysis
  21. Effects of T cell-induced colonic inflammation on epithelial barrier function†
  22. Seroreactivity to microbial components in Crohn's disease is associated with ileal involvement, noninflammatory disease behavior and NOD2/CARD15 genotype, but not with risk for surgery in a Hungarian cohort of IBD patients
  23. Multidrug resistance gene-1 polymorphisms and resistance to cyclosporine a in patients with steroid resistant ulcerative colitis
  24. Dangers associated with endoscopic management of strictures in IBD
  25. Role of the interleukin 24 in patients with ulcerative colitis
  26. Antibodies Against Cyclic Citrullinated Peptide (CCP) in Inflammatory Bowel Disease Patients With or Without Arthritic Manifestations
  27. Nitric Oxide and Colitis: Rats, Humans and Now Macaques
  28. Distinct Microbiome in Pouchitis Compared to Healthy Pouches in Ulcerative Colitis and Familial Adenomatous Polyposis
  29. Is Crohn's creeping fat an adipose tissue?
  30. Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease
  31. Cyclosporine in the management of severe ulcerative colitis while breast-feeding
  32. Nailing down the shingles in IBD
  33. Local Injection of Infliximab in Symptomatic Isolated Mucosal LesionsA Novel Scenario for Endoscopic Therapy?
  34. A New Type of Strictureplasty for the Treatment of Multiple Long Stenosis in Crohn's Disease

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