Authors: Ippoliti Andrew Devlin Shane Mei Ling Yang Huiying Papadakis Konstantinos A Vasiliauskas Eric A McGovern Dermot PB Abreu Maria T Melmed Gil Shaye Omid Enayati Pedram Chen Gary Choi Jennifer Taylor Kent Landers Carol J Rotter Jerome I Targan Stephan R
Publish Date: 2010/08/01
Volume: 16, Issue: 8, Pages: 1279-1285
Abstract
Andrew Ippoliti Shane Devlin Ling Mei Huiying Yang Konstantinos A Papadakis Eric A Vasiliauskas Dermot PB McGovern Maria T Abreu Gil Melmed Omid Shaye Pedram Enayati Gary Chen Jennifer Choi Kent Taylor Carol J Landers Jerome I Rotter Stephan R Targan Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohns disease† Inflammatory Bowel Diseases Volume 16 Issue 8 1 August 2010 Pages 1279–1285 https//doiorg/101002/ibd21196Mutations in the nucleotide oligomerization domain2 NOD2 gene and positive antibodies to microbial antigens have been found to be associated with the Crohns disease CD phenotype fibrostenosis The aim of this study was to confirm these relationships in a large cohort of CD patients and to determine the correlation between the presence of NOD2 variants and antibodies to oligomannan CBir outer membrane porinC OmpC and I2 in CD patients with fibrostenosisSera and DNA from 731 unrelated CD patients were tested for NOD2 variants SNP 8 12 and 13 and the antibodies The results were correlated with CD phenotypes fibrostenosis internal penetrating perianal penetrating and ulcerative colitis UClike as well as other clinical featuresThe presence of NOD2 allelic variants was primarily associated with fibrostenosis secondarily with small bowel disease and small bowel surgery and was inversely associated with UClike disease This association was present in patients with a fibrostenosis only Vienna B2 and those with both stricturing and penetrating disease The presence and level of antibodies to microbial antigens was also associated with the fibrostenosis phenotype In the 316 patients with fibrostenosis the prevalence of NOD2 variants was significantly correlated with the antibody titer by quartile sum score Further when these patients with fibrostenosis were clustered by quartile sum score the odds ratio for fibrostenosis was significantly higher in the patients with NOD2 variant alleles within each cluster indicating synergy
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