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Title of Journal: Inflamm Bowel Dis

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Abbravation: Inflammatory Bowel Diseases

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Narnia

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DOI

10.1007/bf02714376

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1078-0998

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Distinct Microbiome in Pouchitis Compared to Healt

Authors: Zella Garrett C Hait Elizabeth J Glavan Tiffany Gevers Dirk Ward Doyle V Kitts Christopher L Korzenik Joshua R
Publish Date: 2011/05/01
Volume: 17, Issue: 5, Pages: 1092-1100
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Abstract

Garrett C Zella Elizabeth J Hait Tiffany Glavan Dirk Gevers Doyle V Ward Christopher L Kitts Joshua R Korzenik Distinct Microbiome in Pouchitis Compared to Healthy Pouches in Ulcerative Colitis and Familial Adenomatous Polyposis Inflammatory Bowel Diseases Volume 17 Issue 5 1 May 2011 Pages 1092–1100 https//doiorg/101002/ibd21460Pouchitis occurs in up to 50 of patients with ulcerative colitis UC undergoing ileal pouch anal anastomosis IPAA Pouchitis rarely occurs in patients with familial adenomatous polyposis FAP who undergo IPAA Our aim was to compare mucosal and luminal flora in patients with UCassociated pouchitis UCP healthy UC pouches HUC and healthy FAP pouches FAPNineteen patients were enrolled in this crosssectional study nine UCP three HUC seven FAP Patients with active pouchitis were identified using the Pouchitis Disease Activity Index PDAI Ileal pouch mucosal biopsies and fecal samples were analyzed with a 16S rDNAbased terminal restriction fragment length polymorphism TRFLP approach Pooled fecal DNA from four UCP and four FAP pouches were sequenced for further speciationTRFLP data revealed statistically significant differences in the mucosal and fecal microbiota between each group of patients UCP samples exhibited significantly more TRFLP peaks matching Clostridium and Eubacterium genera compared to HUC and FAP pouches and fewer peaks matching Lactobacillus and Streptococcus genera compared to FAP DNA Sanger sequencing of a subset of luminal samples revealed UCP having more identifiable sequences of Firmicutes 512 versus 212 and Verrucomicrobia 202 versus 32 and fewer Bacteroidetes 179 versus 605 and Proteobacteria 98 versus 147 compared to FAP

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References

citation journal title=J Med Microbiol citation year=2006 citation volume=55 citation pages=11411149

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