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Title of Journal: Inflamm Bowel Dis

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Abbravation: Inflammatory Bowel Diseases

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Narnia

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DOI

10.1016/0029-7844(96)00210-4

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1078-0998

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Gene Expression Profiling Identifies Mechanisms of

Authors: Mariman Rob Kremer Bas van Erk Marjan Lagerweij Tonny Koning Frits Nagelkerken Lex
Publish Date: 2012/08/01
Volume: 18, Issue: 8, Pages: 1424-1433
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Abstract

Rob Mariman Bas Kremer Marjan van Erk Tonny Lagerweij Frits Koning Lex Nagelkerken Gene Expression Profiling Identifies Mechanisms of Protection to Recurrent Trinitrobenzene Sulfonic Acid Colitis Mediated by Probiotics Inflammatory Bowel Diseases Volume 18 Issue 8 1 August 2012 Pages 1424–1433 https//doiorg/101002/ibd22849Host–microbiota interactions in the intestinal mucosa play a major role in intestinal immune homeostasis and control the threshold of local inflammation The aim of this study was to evaluate the efficacy of probiotics in the recurrent trinitrobenzene sulfonic acid TNBSinduced colitis model and gain more insight into protective mechanismsLongterm administration of Lactobacillus plantarum NCIMB8826 or the probiotic mixture VSL3 reduced intestinal inflammation induced by TNBS evident from improved colon morphology and less influx of innate CD11b+ and adaptive CD4+/CD8+ immune cells in the intestinal mucosa and decreased proinflammatory serum cytokines interferongamma IFNγ interleukin IL17 IL1β monocyte chemoattractant protein MCP1 in probiotictreated mice Genomewide expression analysis of colonic tissues using microarrays revealed differences in expression of genes related to inflammation and immune processes between untreated and probiotic treated mice Principal component analysis revealed that probiotic treatment resulted in a shift of gene expression profiles toward those of healthy controls Effects of probiotics on colonic gene expression were most profound during active inflammation in particular on gene clusters related to mast cells and antimicrobial peptides The results were substantiated by suppression of chemokine gene expression

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References

citation journal title=Inflamm Bowel Dis citation year=2008 citation volume=14 citation pages=15971605

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  1. Gender and Location of CRC in IBDImplications for Surveillance Protocols
  2. Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent
  3. Targeting TNF in Postoperative Recurrence of Crohn's Disease:Can We Extinguish the Fire Before It Starts?
  4. Adalimumab Therapy in Crohn's Disease of the Ileal Pouch
  5. Observations on Severity and Activity Indices in a Therapeutic Trial of Active Crohn's Disease
  6. Splenic function and IgM-memory B cells in Crohn's disease patients treated with infliximab
  7. One-year Investigator-blind Randomized Multicenter Trial Comparing Asacol 2.4 g Once Daily with 800 mg Three Times Daily for Maintenance of Remission in Ulcerative Colitis
  8. Role of diet in the development of inflammatory bowel disease
  9. Thromboembolism in pediatric inflammatory bowel disease: Systematic review
  10. Potential Oncogenic Properties of Mobilized Stem Cells in a Subpopulation of Inflammatory Bowel Disease Patients Infected with Helicobacter pylori
  11. Potential Oncogenic Properties of Mobilized Stem Cells in a Subpopulation of Inflammatory Bowel Disease Patients Infected with Helicobacter pylori
  12. Twin Studies Reveal Specific Imbalances in the Mucosaassociated Microbiota of Patients with Ileal Crohn's Disease
  13. Microbial Causation of the Chronic Idiopathic Inflammatory Bowel Diseases
  14. Babesiosis in a Patient on Infliximab for Crohn's Disease
  15. Plasma Chromogranin A in Patients With Inflammatory Bowel Disease: A Possible Explanation
  16. Effect of Adalimumab on Clinical Laboratory Parameters in Patients with Crohn's Disease: Results from the CHARM Trial
  17. Natural history of bone metabolism and bone mineral density in children with inflammatory bowel disease
  18. What is the incidence, prevalence, and natural history of indeterminate colitis?
  19. Anti-tumor Necrosis Factor and Postoperative Complications in Crohn's Disease: Systematic Review and Meta-analysis
  20. Effects of T cell-induced colonic inflammation on epithelial barrier function†
  21. Seroreactivity to microbial components in Crohn's disease is associated with ileal involvement, noninflammatory disease behavior and NOD2/CARD15 genotype, but not with risk for surgery in a Hungarian cohort of IBD patients
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  24. Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease†
  25. Role of the interleukin 24 in patients with ulcerative colitis
  26. Antibodies Against Cyclic Citrullinated Peptide (CCP) in Inflammatory Bowel Disease Patients With or Without Arthritic Manifestations
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  28. Distinct Microbiome in Pouchitis Compared to Healthy Pouches in Ulcerative Colitis and Familial Adenomatous Polyposis
  29. Is Crohn's creeping fat an adipose tissue?
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