Authors: Moran G W McLaughlin J T
Publish Date: 2010/06/01
Volume: 16, Issue: 6, Pages: 914-915
Abstract
We read with interest the results of the study by Sciola et al1 In a large cohort of patients with active ulcerative colitis UC or Crohns disease CD the plasma chromogranin A CgA concentration was significantly increased in inflammatory bowel disease IBD when compared to controls This is an important discovery about this enteroendocrine cell EEC marker that could have ramifications beyond those described in the studyActive inflammation and not diseasespecific pathways seem to drive this response as plasma CgA was significantly higher in active rather than quiescent disease This expression was correlated to TNFα expression the extent of disease and disease activity but no association was found with IBD type routine biochemical parameters or disease activity indices In addition the expression at the plasma level was not translated to the tissue level as immunohistological
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