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Title of Journal: Int J Colorectal Dis

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Abbravation: International Journal of Colorectal Disease

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Springer-Verlag

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DOI

10.1007/s12678-013-0132-7

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1432-1262

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Appendectomy tonsillectomy and risk of inflammat

Authors: Farzad Firouzi Ali Bahari Rahim Aghazadeh Mohammad Reza Zali
Publish Date: 2005/06/04
Volume: 21, Issue: 2, Pages: 155-159
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Abstract

There is some controversy about the prevalence of appendectomy and tonsillectomy among patients with Crohn’s disease and a lower rate of appendectomy among patients with ulcerative colitis UC The objective of this study was to elucidate the role of appendectomy and tonsillectomy in Iranian patients with inflammatory bowel disease IBD Three hundred and eightytwo consecutive cases of UC and 46 cases of CD were included Age and sexmatched controls were randomly selected A total of 382 controls for UC and 184 controls for CD were enrolled A standard record concerning smoking habit history of appendectomy and tonsillectomy OCP and NSAID use was completed Logistic regression analysis was used to evaluate potential confounding variables Twelve patients 31 with UC reported a previous history of appendectomy compared with 30 controls 79 OR=038 95CI=019–076 P0004 Appendectomy was reported by five patients 109 with CD compared with four controls 22 OR=549 95CI=141–2134 P002 The logistic regression analysis showed that appendectomy is a risk factor in CD but has a modest protective effect for development of UC No association with tonsillectomy was found for either disease A statistically significant protective effect for smoking in UC was found OR=02 95CI=013–032 P00001 We have found an inverse association between OCP and NSAID use with UC but not CD P00001 and P0001 respectively Appendectomy is protective in UC but a risk factor in CD among Iranian population Tonsillectomy was not associated with either UC or CD disease UC but not CD is a disease of nonsmokers The inverse association between ulcerative colitis and OCP or NSAID in the Iranian population is noted

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