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Title of Journal: Int J Colorectal Dis

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Abbravation: International Journal of Colorectal Disease

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Springer-Verlag

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DOI

10.1007/bf03034364

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1432-1262

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Haemorrhoids are related to changes of cell functi

Authors: Christian Klink Marcel Binnebösel Daniel Kämmer Stefan Willis Andreas Prescher Uwe Klinge Volker Schumpelick
Publish Date: 2009/07/10
Volume: 24, Issue: 12, Pages: 1389-1394
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Abstract

Epidemiology and risk factors of haemorrhoidal disease are not well defined This study tried to evaluate if the appearance of haemorrhoids is related to a disturbed remodelling of the soft tissue of rectal mucosa and submucosa Therefore immunohistochemical expression profiles of five parameters as potential mediators in neoangiogenesis EGFR in inflammatory cell activity COX2 and in cell migration differentiation and wound healing notch3 cmyc and ßCatenin were analysed Saed et al Fertil Steril 83Suppl 11216–1219 1 Saed et al Fertil Steril 791404–1408 2 Stojadinovic et al Am J Pathol 16759–69 3Haemorrhoidal tissue specimens were collected from 44 patients Healthy rectal mucosa was obtained from 16 nonfixed fresh cadavers and served as control Histological and immunohistochemical markers like EGFR COX2 notch3 cmyc and ßCatenin were analysed semiquantitatively separately for mucosal and submucosal layer

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