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Title of Journal: Int J Colorectal Dis

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Abbravation: International Journal of Colorectal Disease

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Springer-Verlag

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DOI

10.1016/0025-5408(83)90044-2

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1432-1262

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Association of NQO1 Pro187Ser polymorphism with th

Authors: JueYu Zhou Rong Shi HaiLang Yu WenLing Zheng WenLi Ma
Publish Date: 2011/11/26
Volume: 27, Issue: 8, Pages: 1123-1124
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Abstract

The development of colorectal neoplasia is determined by a series of risk factors such as genetic polymorphisms environmental factors lifestyle habits and the complex interaction between these factors Both environmental and genetic factors contribute to the pathogenesis as well as prevention of human colorectal neoplasia An important biotransformation enzyme that may play a role in the detoxification of dietary and other carcinogens is NQO1 and its polymorphism in codon 187 C609T Pro187Ser rs1800566 resulting in an inactive enzyme has been associated with the risk of various cancers such as renal lung bladder and breast cancer Several epidemiological studies indicated the association between NQO1 Pro187Ser polymorphism and the risks of colorectal cancer CRC and colorectal adenoma CRA but the results remain conflicting rather than conclusiveThis work was supported by Nature Science Foundation of Guangdong Province China S2011040003050 Science and Technology Planning Project of Guangdong Province China 2009B060700112 and Foundation for Distinguished Young Talents in Higher Education of Guangdong China LYM09045

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