Authors: Xiaojuan Wu Hongyi Zhang Ning Li Maosheng Yan Jia Wei Donghai Yu Jiexiong Feng
Publish Date: 2013/04/09
Volume: 28, Issue: 5, Pages: 689-696
Abstract
Between 1998 and 2008 967 patients with suspected intestinal dysganglionosis underwent surgical treatment at the pediatric surgery department of Tongji Hospital The diagnosis of HD or HAD was confirmed by postoperative pathological examination All patients underwent preoperative workup including barium enema anorectal manometry and histochemical acetylcholinesterase staining of rectal mucosa Known risk factors for IDs were recorded The predicting score was calculated by summing the scores of the risk factors and three preoperative tests The sensitivity specificity accuracy positive predictive values negative predictive values positive likelihood ratios and negative likelihood ratios of the predicting score were calculated The cutoff score for predicting HD was determined using receiver operating characteristic ROC analysis The accuracy of the predicting score was measured by the area under the ROC curveFailed or delayed passage of meconium age 3 years and male gender were risk factors associated with HD The area under the ROC curve of the predicting score was 0927 95 confidence interval 0910–0944 A predicting score of more than 5 was used as a cutoff for predicting HD The scoring system achieved 831 sensitivity 895 specificity and 859 accuracy in predicting HD
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