Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Int J Colorectal Dis

Search In Journal Title:

Abbravation: International Journal of Colorectal Disease

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

DOI

10.1016/j.aorn.2010.04.016

Search In DOI:

ISSN

1432-1262

Search In ISSN:
Search In Title Of Papers:

Spatiotemporal pattern analysis of transcription f

Authors: Tao Zhang Yu Zuo Bai Da Jia Wang Hui Min Jia Zheng Wei Yuan Wei Lin Wang
Publish Date: 2009/04/22
Volume: 24, Issue: 9, Pages: 1039-1047
PDF Link

Abstract

As a member of the transcription factors family transcription factor 4Tcf4 is known to influence gene expression in endodermally derived tissues including lung liver pancreas stomach and intestine However it remained unknown if this capability is active during anorectal development in the normal and anorectal malformations ARM rat embryosIn this study ethylenethiourea ETUinduced ARM model was introduced to investigate the expression pattern of Tcf4 during anorectal development using immunohistochemical staining reverse transcriptase polymerase chain reaction RTPCR and Western blot analysisImmunostaining revealed that Tcf4 expression showed spacedependent changes in the developing anorectum in normal embryos Tcf4 protein is initially expressed in the dorsal endoderm of urorectal septum URS and hindgut on embryonic day 13 E13 Additionally separate expression domain develops intensively on the dorsal CM on E14 On E15 positive cells are then detected in the fused tissue of URS and prominently in the anal membrane In the ARM embryos however the epithelium of the cloaca URS and anorectum was negative or faint for Tcf4 In Western blot and RTPCR timedependent changes of Tcf4 protein and mRNA expression were remarkable during the anorectal development on E14 E145 and E15 the expression level reached the peak after E16 Tcf4 expression gradually decreased In contrast in ARM embryos spatiotemporal expression of Tcf4 was imbalanced during the anorectal morphogenesis from E13 to E16

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Current perioperative practice in rectal surgery in Austria and Germany
  2. Shortcomings in colonic stenting to palliate large bowel obstruction from extracolonic malignancies
  3. Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences
  4. A high lymph node yield in colon cancer is associated with age, tumour stage, tumour sub-site and priority of surgery. Results from a prospective national cohort study
  5. Dietary restrictions for acute diverticulitis: evidence-based or expert opinion?
  6. Long-term results of botulinum toxin for the treatment of chronic anal fissure: prospective clinical and manometric study
  7. Certolizumab pegol, a monthly subcutaneously administered Fc-free anti-TNFα, improves health-related quality of life in patients with moderate to severe Crohn’s disease
  8. Impact of preoperative targeted therapy on postoperative complications after resection of colorectal liver metastases
  9. A new diagnostic scoring system to differentiate Hirschsprung’s disease from Hirschsprung’s disease-allied disorders in patients with suspected intestinal dysganglionosis
  10. A systematic review and meta-analysis of adjuvant chemotherapy after neoadjuvant treatment and surgery for rectal cancer
  11. Impact of fat obesity on laparoscopic total mesorectal excision: more reliable indicator than body mass index
  12. Occurrence of adenomas in the pouch and small intestine of FAP patients after proctocolectomy with ileoanal pouch construction
  13. Clinical and instrumental parameters in patients with constipation and incontinence: their potential implications in the functional aspects of these disorders
  14. Colonoscopy as a useful tool in determining the transition zone in transanal endorectal pull-through in Hirschsprung’s disease
  15. Risk of advanced metachronous colorectal adenoma during long-term follow-up
  16. Overall survival after resection for colon cancer in a national cohort study was adversely affected by TNM stage, lymph node ratio, gender, and old age
  17. L -arginine and glycine supplementation in the repair of the irradiated colonic wall of rats
  18. A observational study of the efficacy and safety of capecitabine versus bolus infusional 5-fluorouracil in pre-operative chemoradiotherapy for locally advanced rectal cancer
  19. “Pseudocarcinomatosis peritoneii”: extensive intraperitoneal endometriosis mimic carcinomatosis in morphology—a case report and a survey of the literature
  20. Long-term results of laparoscopy-assisted radical right hemicolectomy with D3 lymphadenectomy: clinical analysis with 177 cases
  21. Permanent sacral nerve modulation for fecal incontinence and associated urinary disturbances
  22. Adenocarcinoma in the ileal pouch: early detection and potential role of fecal DNA methylated markers in surveillance
  23. Analysis of the factors related to the decision of restoring intestinal continuity after Hartmann’s procedure
  24. Sacral neuromodulation for fecal incontinence and constipation in adult patients with anorectal malformation—a feasibility study in patients with or without sacral dysgenesis
  25. Tetrandrine ameliorates dextran-sulfate-sodium-induced colitis in mice through inhibition of nuclear factor -κB activation
  26. Colonic irrigation for defecation disorders after dynamic graciloplasty
  27. Local excision of low rectal cancer treated by chemoradiotherapy: is it safe for all patients with suspicion of complete tumor response?
  28. In reply to Tin et al.
  29. Rectal cancer surgery: volume–outcome analysis
  30. Signet-ring cell carcinoma of the rectum and synchronous renal cell carcinoma in a young man
  31. Long-term follow-up and development of diverticulitis in patients diagnosed with diverticulosis of the colon
  32. Fecal transplant is as effective and safe in immunocompromised as non-immunocompromised patients for Clostridium difficile
  33. DNA variants in the ATM gene are not associated with sporadic rectal cancer in a Norwegian population-based study
  34. Adequacy of lymph node yield and staging in rectal cancer should not be determined based on a minimum number of lymph nodes evaluated
  35. Failure of a meta-analysis on the role of elective surgery for left colonic diverticulitis in young patients
  36. Long-segment hypoplasia of the left hemicolon 4 months after sigmoid resection and loop transversostomy in a patient with intestinal endometriosis
  37. Invited commentary on “Werkgartner G. et al.: laparoscopic versus open appendectomy for complicated appendicitis in high risk patients”
  38. Long-term survival after resection of extrahepatic recurrence of hepatocellular carcinoma at the right colon
  39. Association of NQO1 Pro187Ser polymorphism with the risks for colorectal cancer and colorectal adenoma: a meta-analysis
  40. Caspase-3 activity, response to chemotherapy and clinical outcome in patients with colon cancer
  41. Erratum to: Successful implantation of autologous muscle-derived stem cells in treatment of faecal incontinence due to external sphincter rupture
  42. Experiences of two centers of bariatric surgery in the treatment of intragastrale band migration after gastric banding—the importance of the German multicenter observational study for quality assurance in obesity surgery 2005 and 2006
  43. Infliximab versus cyclosporine as rescue therapy in acute severe steroid-refractory ulcerative colitis: a systematic review and meta-analysis
  44. Haemorrhoids are related to changes of cell function in mucosa and submucosa
  45. Urinary and sexual dysfunction rates and risk factors following rectal cancer surgery
  46. Anal inspection and digital rectal examination compared to anorectal physiology tests and endoanal ultrasonography in evaluating fecal incontinence
  47. ErbB family immunohistochemical expression in colorectal cancer patients with higher risk of recurrence after radical surgery
  48. Prophylactic stoma mesh did not prevent parastomal hernias
  49. Level of arterial ligation in total mesorectal excision (TME): an anatomical study
  50. Gender differences in the trend of colorectal cancer incidence in Singapore, 1968–2002
  51. Long-term outcome of extralevator abdominoperineal excision (ELAPE) for low rectal cancer
  52. Systemic and local evidence of increased Fas-mediated apoptosis in ulcerative colitis
  53. Appendectomy, tonsillectomy, and risk of inflammatory bowel disease: a case control study in Iran
  54. A rare case of intra-cardiac metastasis from an appendiceal carcinoid tumour without liver metastases
  55. Prognostic value of carcinoembryonic antigen level in rectal cancer treated with neoadjuvant chemoradiotherapy
  56. Short-course radiotherapy with delayed surgery in unfit locally advanced rectal cancer patients
  57. Skeletal muscle disorders associated with inflammatory bowel diseases: occurrence of myositis in a patient with ulcerative colitis and Hashimoto's thyroiditis—case report and review of the literature
Search Result: