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Title of Journal: Int J Colorectal Dis

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Abbravation: International Journal of Colorectal Disease

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Springer-Verlag

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DOI

10.1002/eej.4390990517

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1432-1262

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Caspase3 activity response to chemotherapy and c

Authors: Javier de Oca Daniel Azuara Raquel SanchezSantos Matilde Navarro Gabriel Capella Victor Moreno Anna Sola Georgina Hotter Sebastiano Biondo Alfonso Osorio Joan MartíRagué Antoni Rafecas
Publish Date: 2007/09/04
Volume: 23, Issue: 1, Pages: 21-27
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Abstract

The prognostic value of the degree of apoptosis in colorectal cancer is controversial This study evaluates the putative clinical usefulness of measuring caspase3 activity as a prognostic factor in colonic cancer patients receiving 5fluoracil adjuvant chemotherapyWe evaluated caspase3like protease activity in tumours and in normal colon tissue Specimens were studied from 54 patients These patients had either stage III cancer Dukes stage C or highrisk stage II cancer Dukes stage B2 with invasion of adjacent organs lymphatic or vascular infiltration or carcinoembryonic antigen CEA  5 Median followup was 73 months Univariate analysis was performed previously to explore the relation of different variables age sex preoperative CEA tumour size Dukes stage vascular invasion lymphatic invasion caspase3 activity in tumour and caspase3 activity in normal mucosa as prognostic factors of tumour recurrence after chemotherapy treatment Subsequently a multivariate Cox regression model was performedMedian values of caspase3 activity in tumours were more than twice those in normal mucosa 881 vs 406 U p = 0001 showing a statistically significant correlation r = 034 Significant prognostic factors of recurrence in multivariate analysis were male sex odds ratio OR = 353 113–1090 p = 002 age OR = 109 101–118 p = 003 Dukes stage OR = 193 101–370 caspase3 activity in normal mucosa OR = 102 101–104 p = 0017 and caspase3 activity in tumour OR = 102 101–103 p = 0013Low caspase3 activity in the normal mucosa and tumour are independent prognostic factors of tumour recurrence in patients receiving adjuvant 5fluoracilbased treatment in colon cancer correlating with poor diseasefree survival and higher recurrence rate

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