Authors: G Nusko E G Hahn U Mansmann
Publish Date: 2008/07/03
Volume: 23, Issue: 11, Pages: 1065-1071
Abstract
According to the adenoma–carcinoma concept all colorectal adenomas are to be removed and all patients have to undergo regular surveillance examinations But there is still shortage on information on the longterm results of followup colonoscopy after polypectomyBetween 1978 and 2003 more than 20000 polyps were prospectively documented at the Erlangen Registry of Colorectal Polyps A total of 1091 patients undergoing periodic surveillance examinations are studied for differences between initial and metachronous lesions of the colorectum Statistical analysis using χ 2testing of adenoma characteristics found in four subsequent recurrence periods and calculation of the relative risk RR for the development of metachronous adenomas of advanced pathology was performedIn comparison with the initial findings metachronous adenomas are in general significantly smaller ones p 000001 more frequently tubular lesions p 000001 and bearing less often highgrade dysplasia p 000001 Adenomas of advanced pathology were significantly less often found during followup than at baseline examination p 00001 These differences are found between the initial and four subsequent generations of metachronous adenomas Patients with adenomas of advanced pathology at baseline have a significantly higher risk for metachronous adenomas of advanced pathology RR 151 95CI 104–193 at the first recurrence
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