Authors: Emmanuel C Obusez Yiding Liu Ana E Bennett Feza H Remzi Baochuan Guo Bo Shen
Publish Date: 2010/10/21
Volume: 26, Issue: 7, Pages: 951-953
Abstract
Patients with ulcerative colitis UC are at risk for the development of dysplasia or cancer with cumulative incidence rates of 2 by 10 years 8 by 20 years and 18 by 30 years in a metaanalysis Reported risk factors for dysplasia or cancer are long duration of colitis severe and extensive colitis concomitant primary sclerosing cholangitis family history of colorectal cancer CRC and early age of UC diagnosis Surveillance colonoscopy with biopsy the current gold standard has been shown to reduce mortality of CRC associated with UC The presence of multifocal lowgrade dysplasia LGD flat dysplasia dysplasiaassociated mass or lesion and highgrade dysplasia HGD or CRC warrants colectomy in patients with UC Restorative proctocolectomy RPC with ileal pouch–anal anastomosis IPAA is the definitive surgical treatment for patients with UCassociated neoplasia
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