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Title of Journal: Int J Colorectal Dis

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Abbravation: International Journal of Colorectal Disease

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Springer-Verlag

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DOI

10.1007/s00401-014-1347-2

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1432-1262

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Emphasis Type="SmallCaps"L/Emphasisarginine a

Authors: Etiene de Aguiar Picanço Francisco LopesPaulo Ruy G Marques Cristina F Diestel Carlos Eduardo R Caetano Mônica Vieira Mano de Souza Gabriela Mendes Moscoso Helena Maria F Pazos
Publish Date: 2011/02/25
Volume: 26, Issue: 5, Pages: 561-568
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Abstract

Forty male Wistar rats were randomly divided into four groups I—healthy II—irradiated with no amino acid supplementation III—irradiated and supplemented with Larginine and IV—irradiated and supplemented with glycine The animals received supplementation for 14 days with irradiation being applied on the eighth day of the experiment All animals underwent laparotomy on the 15th day for resection of a colonic segment for stereologic analysis Parametric and nonparametric tests were used for statistical analysis with the level of significance set at p ≤005Stereologic analysis showed that irradiation induced a reduction of the total volume of the colon wall of group II and III animals compared to healthy controls but not of group IV animals supplemented with glycine The mucosal layer of the irradiated animals of all groups was reduced compared to healthy group I animals but supplementation with Larginine and glycine was effective in maintaining the epithelial surface of the mucosal layerThe present results suggest that glycine supplementation had a superior effect on the irradiated colon wall compared to Larginine supplementation since it was able to maintain the thickness of the wall and the epithelial surface of the mucosa whereas Larginine maintained the partial volume of the epithelium and the epithelial surface but not the total volume of the intestinal wall

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