Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Int J Colorectal Dis

Search In Journal Title:

Abbravation: International Journal of Colorectal Disease

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

DOI

10.1016/0196-6553(85)90013-6

Search In DOI:

ISSN

1432-1262

Search In ISSN:
Search In Title Of Papers:

Overall survival after resection for colon cancer

Authors: Kristian E Storli Karl Søndenaa Ida R K Bukholm Idunn Nesvik Tore Bru Bjørg Furnes Bjarte Hjelmeland Knut B Iversen Geir E Eide
Publish Date: 2011/05/12
Volume: 26, Issue: 10, Pages: 1299-1307
PDF Link

Abstract

A national surveillance program of colon cancer treatment was introduced in 2007 We examined prognostic factors for colon cancer operated in 2000 with an aim of improving survival in the new program and a special focus on the merit of lymph node yieldOverall 5year survival was 580 and overall hospital mortality was 52 with 45 in elective cases and 125 after urgent surgery In only 411 of the specimens were 12 or more lymph nodes retrieved but this did not affect survival in the combined cohort although one of the hospitals achieved a significantly better result with a harvest of 12 or more lymph nodes In a multivariate analysis old age gender a high lymph node ratio LNR at stage III and tumor–node–metastasis stage were adverse factors for survivalThe operative mortality was high and should be reassessed The lymph node count did not have a significant impact on outcome overall whereas the LNR proved significant for stage III A prospective protocol using overall lymph node yield as a surrogate measure for more radical surgery nevertheless seems warranted to improve the lymph node harvest according to international recommendationsIn recent years the results after surgery for rectal cancer in Norway with a 5year overall survival OS rate of 601 has surpassed that of colon cancer at 575 1 This has been achieved because the surgical technique has been standardized according to total mesorectal excision TME with subsequent dramatic reductions of local recurrences Beginning in 2007 all colon cancers were to be reported separately to the Norwegian National Cancer Registry in an effort to systematically survey and hopefully improve results Nevertheless a national strategy to standardize surgical treatment along the lines of radical surgery has neither been implemented in detail nor been generally accepted 2 3In this respect the number of lymph nodes retrieved may act as a surrogate measure of radical surgery The survival benefit of a large lymph node harvest has been shown in several reports 2 3 4 It has been accepted nationally to offer patients with tumor–node–metastasis TNM stage III below a certain age usually 75 years adjuvant chemotherapy This depends on adequate staging and lymph node sampling It has been decided that a rather arbitrary level of 12 retrieved nodes is enough to obtain adequate surgery and staging Pathologists may be a key factor for optimal lymph node harvest and a conjoined effort between surgeon and pathologist would be ideal to improve results 2 3 4 5 6The aim of the study was to examine after modest radical colon surgery removing mesocolic nodes and focus on lymph node yield what would influence survival and where surgical improvement might be possible using data from a cohort of patients from three large Norwegian teaching hospitalsPatients from a national cohort were operated in 2000 and followup was until December 2007 a mean of 75 years later Three teaching community hospitals Haraldsplass Deaconal Hospital Stavanger University Hospital and Akershus University Hospital contributed patients


Keywords:

References


.
Search In Abstract Of Papers:
Other Papers In This Journal:

  1. Current perioperative practice in rectal surgery in Austria and Germany
  2. Shortcomings in colonic stenting to palliate large bowel obstruction from extracolonic malignancies
  3. Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences
  4. A high lymph node yield in colon cancer is associated with age, tumour stage, tumour sub-site and priority of surgery. Results from a prospective national cohort study
  5. Dietary restrictions for acute diverticulitis: evidence-based or expert opinion?
  6. Long-term results of botulinum toxin for the treatment of chronic anal fissure: prospective clinical and manometric study
  7. Certolizumab pegol, a monthly subcutaneously administered Fc-free anti-TNFα, improves health-related quality of life in patients with moderate to severe Crohn’s disease
  8. Impact of preoperative targeted therapy on postoperative complications after resection of colorectal liver metastases
  9. Spatiotemporal pattern analysis of transcription factor 4 in the developing anorectum of the rat embryo with anorectal malformations
  10. A new diagnostic scoring system to differentiate Hirschsprung’s disease from Hirschsprung’s disease-allied disorders in patients with suspected intestinal dysganglionosis
  11. A systematic review and meta-analysis of adjuvant chemotherapy after neoadjuvant treatment and surgery for rectal cancer
  12. Impact of fat obesity on laparoscopic total mesorectal excision: more reliable indicator than body mass index
  13. Occurrence of adenomas in the pouch and small intestine of FAP patients after proctocolectomy with ileoanal pouch construction
  14. Clinical and instrumental parameters in patients with constipation and incontinence: their potential implications in the functional aspects of these disorders
  15. Colonoscopy as a useful tool in determining the transition zone in transanal endorectal pull-through in Hirschsprung’s disease
  16. Risk of advanced metachronous colorectal adenoma during long-term follow-up
  17. L -arginine and glycine supplementation in the repair of the irradiated colonic wall of rats
  18. A observational study of the efficacy and safety of capecitabine versus bolus infusional 5-fluorouracil in pre-operative chemoradiotherapy for locally advanced rectal cancer
  19. “Pseudocarcinomatosis peritoneii”: extensive intraperitoneal endometriosis mimic carcinomatosis in morphology—a case report and a survey of the literature
  20. Long-term results of laparoscopy-assisted radical right hemicolectomy with D3 lymphadenectomy: clinical analysis with 177 cases
  21. Permanent sacral nerve modulation for fecal incontinence and associated urinary disturbances
  22. Adenocarcinoma in the ileal pouch: early detection and potential role of fecal DNA methylated markers in surveillance
  23. Analysis of the factors related to the decision of restoring intestinal continuity after Hartmann’s procedure
  24. Sacral neuromodulation for fecal incontinence and constipation in adult patients with anorectal malformation—a feasibility study in patients with or without sacral dysgenesis
  25. Tetrandrine ameliorates dextran-sulfate-sodium-induced colitis in mice through inhibition of nuclear factor -κB activation
  26. Colonic irrigation for defecation disorders after dynamic graciloplasty
  27. Local excision of low rectal cancer treated by chemoradiotherapy: is it safe for all patients with suspicion of complete tumor response?
  28. In reply to Tin et al.
  29. Rectal cancer surgery: volume–outcome analysis
  30. Signet-ring cell carcinoma of the rectum and synchronous renal cell carcinoma in a young man
  31. Long-term follow-up and development of diverticulitis in patients diagnosed with diverticulosis of the colon
  32. Fecal transplant is as effective and safe in immunocompromised as non-immunocompromised patients for Clostridium difficile
  33. DNA variants in the ATM gene are not associated with sporadic rectal cancer in a Norwegian population-based study
  34. Adequacy of lymph node yield and staging in rectal cancer should not be determined based on a minimum number of lymph nodes evaluated
  35. Failure of a meta-analysis on the role of elective surgery for left colonic diverticulitis in young patients
  36. Long-segment hypoplasia of the left hemicolon 4 months after sigmoid resection and loop transversostomy in a patient with intestinal endometriosis
  37. Invited commentary on “Werkgartner G. et al.: laparoscopic versus open appendectomy for complicated appendicitis in high risk patients”
  38. Long-term survival after resection of extrahepatic recurrence of hepatocellular carcinoma at the right colon
  39. Association of NQO1 Pro187Ser polymorphism with the risks for colorectal cancer and colorectal adenoma: a meta-analysis
  40. Caspase-3 activity, response to chemotherapy and clinical outcome in patients with colon cancer
  41. Erratum to: Successful implantation of autologous muscle-derived stem cells in treatment of faecal incontinence due to external sphincter rupture
  42. Experiences of two centers of bariatric surgery in the treatment of intragastrale band migration after gastric banding—the importance of the German multicenter observational study for quality assurance in obesity surgery 2005 and 2006
  43. Infliximab versus cyclosporine as rescue therapy in acute severe steroid-refractory ulcerative colitis: a systematic review and meta-analysis
  44. Haemorrhoids are related to changes of cell function in mucosa and submucosa
  45. Urinary and sexual dysfunction rates and risk factors following rectal cancer surgery
  46. Anal inspection and digital rectal examination compared to anorectal physiology tests and endoanal ultrasonography in evaluating fecal incontinence
  47. ErbB family immunohistochemical expression in colorectal cancer patients with higher risk of recurrence after radical surgery
  48. Prophylactic stoma mesh did not prevent parastomal hernias
  49. Level of arterial ligation in total mesorectal excision (TME): an anatomical study
  50. Gender differences in the trend of colorectal cancer incidence in Singapore, 1968–2002
  51. Long-term outcome of extralevator abdominoperineal excision (ELAPE) for low rectal cancer
  52. Systemic and local evidence of increased Fas-mediated apoptosis in ulcerative colitis
  53. Appendectomy, tonsillectomy, and risk of inflammatory bowel disease: a case control study in Iran
  54. A rare case of intra-cardiac metastasis from an appendiceal carcinoid tumour without liver metastases
  55. Prognostic value of carcinoembryonic antigen level in rectal cancer treated with neoadjuvant chemoradiotherapy
  56. Short-course radiotherapy with delayed surgery in unfit locally advanced rectal cancer patients
  57. Skeletal muscle disorders associated with inflammatory bowel diseases: occurrence of myositis in a patient with ulcerative colitis and Hashimoto's thyroiditis—case report and review of the literature

Search Result: