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Title of Journal: Chin Sci Bull

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Abbravation: Chinese Science Bulletin

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SP Science in China Press

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DOI

10.1007/s002849900424

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1861-9541

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Spin probes for electron paramagnetic resonance im

Authors: GuoPing Yan Lei Peng ShuangQuan Jian Liang Li Steven Eric Bottle
Publish Date: 2008/12/19
Volume: 53, Issue: 24, Pages: 3777-3789
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Abstract

Electron paramagnetic resonance imaging EPRI is a relatively recent imaging technique which provides potentially multidimensional imaging of the spatial distribution of paramagnetic species Thanks to the use of stable spin probes low frequency EPR imaging has recently allowed the use of large tissue samples or whole animals in vivo in the field of biology and medicine It is normally necessary to introduce prior intravenous or intramuscular infusion of stable or slowly metabolizable nontoxic watersoluble paramagnetic materials or stable implantable particulate materials as spin probes into the system The classification and research progress of spin probes at present were described briefly Three important potential approaches in watersoluble paramagnetic materials design including deuterated sitespecific and macromolecular conjugated nitroxides were also investigatedSupported by National Natural Science Foundation of China Grant No 50773060 Hubei Provincial International Project for Science and Technology Cooperation Grant No 2007CA015 Hubei Provincial Key Technologies Research and Development Program Grant No 2007AA301B24 and 2007 Endeavour Research Award of the Australian Government Grant ERFPDR1942007

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