Authors: WangXin Xue DeQing Zhang GuanXin Zhang DaoBen Zhu
Publish Date: 2011/05/18
Volume: 56, Issue: 18, Pages: 1877-1883
Abstract
The colorimetric response of amineterminated polydiacetylene PDA vesicles was initially demonstrated by varying the pH of the solution Convenient colorimetric methods to detect glucose and acetylcholinesterase AChE activity were successfully established using amineterminated PDA vesicles by taking advantage of the following features 1 the amineterminated PDA vesicles undergo a colorimetric transition as the pH of the solution changes 2 glucose can be oxidized to gluconic acid in the presence of glucose oxidase and 3 AChE catalyzes the hydrolysis of acetylcholine to acetic acid The visual detection of glucose levels and AChE activity showed good selectivity and acceptable sensitivity The detection limit of glucose was ∼25 μmol/L and the level of AChE activity was assayed as low as 100 mU/mL Moreover the amineterminated PDA vesicles can be used for screening the activity of inhibitors against AChEThis article is published under an open access license Please check the Copyright Information section for details of this license and what reuse is permitted If your intended use exceeds what is permitted by the license or if you are unable to locate the licence and reuse information please contact the Rights and Permissions team
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