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Title of Journal: Chin Sci Bull

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Abbravation: Chinese Science Bulletin

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Science China Press

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DOI

10.1007/978-3-642-11458-8_11

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1861-9541

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Detection and analysis of DNA recapture through a

Authors: Ying Hu Zhi Zhou Xinyan Shan Xinghua Lu
Publish Date: 2014/10/01
Volume: 59, Issue: 35, Pages: 4953-4959
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Abstract

Motion control of a single molecule through a solidstate nanopore offers a new perspective on detecting and analyzing single biomolecules Repeat recapture of a single DNA molecule reveals the dynamics in DNA translocation through a nanopore and may significantly increase the signaltonoise ratio for DNA base distinguishing However the transient current at the moment of voltage reversal prevents the observation of instantly recaptured molecules and invalidates the continuous DNA pingpong control We performed and analyzed the DNA translocation and recapture experiment in a silicon nitride solidstate nanopore Numerical calculation of molecular motion clearly shows the recapture dynamics with different delay times The prohibited time when the data acquisition system is saturated by the transient current is derived by equivalent circuit analysis and finite element simulation The COMSOL simulation reveals that the membrane capacitance plays an important role in determining the electric field distribution during the charging process As a result of the transient charging process a nonconstant driving force pulls the DNA back to nanopores faster than theoretically predicted The observed long time constant in the transient current trace is explained by the dielectric absorption of the membrane capacitorThis work was supported by the National Basic Research Program of China 2012CB933002 and Strategic Priority Research Program B of the Chinese Academy of Sciences XDB07030100 X Shan acknowledges the financial aid from Open Research Fund Program of the State Key Laboratory of LowDimensional Quantum Physics KF201201 and X Lu thanks the support of Hundred Talent Program of Chinese Academy of Sciences

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