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Title of Journal: Chin Sci Bull

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Abbravation: Chinese Science Bulletin

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SP Science China Press

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DOI

10.1007/s10894-015-9942-3

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1861-9541

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CD8Superscript+/Superscript T cell response me

Authors: YaJun Yang XiaoZhu Li YaoHe Wang ShengDian Wang
Publish Date: 2012/01/04
Volume: 57, Issue: 1, Pages: 48-53
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Abstract

The role of antitumor immune responses in oncolytic adenoviral therapy has not been well studied due to lack of efficacious tumor model in immunocompetent mice Here we evaluated the contributions of immune components to the therapeutic effects of oncolytic adenoviruse in an immunocompetent murine tumor model permissive for infection and replication of adenovirus We found that CD8+ T cells were critical mediator for antitumor efficacy by oncolytic adenovirus Intratumoral viral therapy induced intensive infiltration of CD8+ T cells in tumor increased tumorspecific IFNγ interferonγ production and CTL cytotoxic T lymphocyte activity of lymphocytes and generated a longterm tumorspecific immune memory Boosting CD8+ T cell responses by agonistic anti41BB cluster differentiation 137 CD137 antibody showed synergistic anticancer effects with oncolytic virotherapy Our results provide insight into antitumor mechanisms of oncolytic adenovirus in addition to their direct oncolytic effectThis article is published under an open access license Please check the Copyright Information section for details of this license and what reuse is permitted If your intended use exceeds what is permitted by the license or if you are unable to locate the licence and reuse information please contact the Rights and Permissions team

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