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Title of Journal: Intensive Care Med

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Abbravation: Intensive Care Medicine

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Springer-Verlag

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ISSN

1432-1238

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Sequential changes in compliance and resistance af

Authors: R Hentschel T Brune N Franke E Harms G Jorch
Publish Date: 2002/04/09
Volume: 28, Issue: 5, Pages: 622-628
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Abstract

Results Cstat first decreased and then increased in both groups In the infusion group Cstat after 90 min was significantly higher than after bolus treatment but not after 15 or 45 min Rrs increased about threefold with large fluctuations in the bolus group After 90 min PaO2/FIO2 had increased from 111±44 to 254±69 in the bolus group and from 86±40 to 238±102 in the infusion group but early FIO2 reduction and increase in PaO2/FIO2 seemed delayed in the infusion groupConclusions Very slow infusion of natural surfactant is at least as effective as bolus instillation in terms of improvement in Cstat and oxygenation after 90 min However until 90 min the course of Cstat and indices of gas exchange seem superior after bolus therapy Because Rrs is substantially increased long expiratory times are required to yield complete exhalation

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