Authors: J Dellamonica N Lerolle C Sargentini S Hubert G Beduneau F Di Marco A Mercat J L Diehl J C M Richard G Bernardin L Brochard
Publish Date: 2013/01/24
Volume: 39, Issue: 6, Pages: 1121-1127
Abstract
Lung volume available for ventilation is markedly decreased during acute respiratory distress syndrome Body positioning may contribute to increase lung volume and partial verticalization is simple to perform This study evaluated whether verticalization had parallel effects on oxygenation and end expiratory lung volume EELVProspective multicenter study in 40 mechanically ventilated patients with ALI/ARDS in five university hospital MICUs We evaluated four 45min successive trunk position epochs supine slightly elevated at 15° semi recumbent with trunk elevated at 45° seated with trunk elevated at 60° and legs down at 45° back to supine Arterial blood gases EELV measured using the nitrogen washin/washout and static compliance were measured Responders were defined by a PaO2/FiO2 increase 20 between supine and seated position Results are median 25th–75th percentilesWith median PEEP = 10 cmH2O verticalization increased lung volume but only responders 13 patients 32 had a significant increase in EELV/PBW predicted body weight compared to baseline This increase persisted at least partially when patients were positioned back to supine Responders had a lower EELV/PBW supine 14 mL/kg 13–15 vs 18 mL/kg 15–27 p = 0005 and a lower compliance 30 mL/cmH2O 22–38 vs 42 30–46 p = 001 than nonresponders Strain decreased with verticalization for responders EELV/PBW increase and PaO2/FiO2 increase were not correlatedVerticalization is easily achieved and improves oxygenation in approximately 32 of the patients together with an increase in EELV Nonetheless effect of verticalization on EELV/PBW is not predictable by PaO2/FiO2 increase its monitoring may be helpful for strain optimizationGeneral Electric provided the “Engström” ventilators for the study and a research grant but had no access to the data the analysis and the interpretation HillRom provided the “TotalCare beds for the study but had no access to the data the analysis and the interpretation
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