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Title of Journal: Intensive Care Med

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Abbravation: Intensive Care Medicine

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Springer-Verlag

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DOI

10.1002/sia.1835

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1432-1238

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Pharmacokinetic/pharmacodynamic analysis of vancom

Authors: Maria del Mar Fernández de Gatta Garcia Natalia Revilla Maria Victoria Calvo Alfonso DomínguezGil Amparo Sánchez Navarro
Publish Date: 2006/12/13
Volume: 33, Issue: 2, Pages: 279-285
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Abstract

Vancomycin clearance and distribution volume were estimated individually assuming a onecompartment pharmacokinetic model PK/PD analysis was performed by Monte Carlo simulation In the ICU patients higher Vd nearly twice the quoted value of 072 l/kg and different vancomycin clearance–creatinine clearance relationship were found Renal function the APACHE score age and serum albumin accounted for more than 65 of drug clearance variability Vancomycin standard dosages led to a 33 risk of not achieving the recommended AUC24h/MIC breakpoint for Staphylococcus aureus

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