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Title of Journal: Intensive Care Med

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Abbravation: Intensive Care Medicine

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Springer-Verlag

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1432-1238

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Cytokeratin 19 fragments in patients with acute lu

Authors: JeanBaptiste Stern Catherine Paugam Pierre Validire Homa AdleBiassette Sandrine Jaffré Monique Dehoux Bruno Crestani
Publish Date: 2006/03/29
Volume: 32, Issue: 6, Pages: 910-914
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Abstract

Cytokeratin 19 CK19 is a specific cytoskeletal structure for alveolar epithelium We hypothesized that the levels of CK19 fragments in bronchoalveolar lavage BAL fluid could serve as an index of epithelial injury and as a prognosis marker in patients with acute lung injury ALI or acute respiratory distress syndrome ARDS The aims of our study were in patients with ALI/ARDS 1 to measure CK19 fragments concentrations in BAL fluid 2 to assess its prognostic value and 3 to identify the cellular source of CK19 in the alveolar spaceThe concentration of BAL CK19 fragments was higher in patients median 4916 pg/ml 25th–75th percentile 2717–10533 than in controls 2208 pg/ml 767–3923 p = 005 and higher in 10 nonsurvivors 7051 pg/ml 4372–13371 than in 12 survivors 2888 pg/ml 1315–5639 p = 003 among ALI/ARDS patients BAL CK19 fragment concentration did not correlate with simplified acute physiologic score lung injury score or PaO2/FIO2 ratio but correlated positively with BAL albumin concentration p = 0002 and with number of BAL macrophages p = 00001 Plasma CK19 fragment concentrations were 10 times lower than those in BAL Immunohistochemical staining for CK19 showed a strong labelling of injured detached epithelial cells and hyperplastic epithelium in ALI/ARDS lung samplesThe electronic reference of this article is http//dxdoiorg/101007/s0013400601247 The online fulltext version of this article includes electronic supplementary material This material is available to authorised users and can be accessed by means of the ESM button beneath the abstract or in the structured fulltext article To cite or link to this article you can use the above reference

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