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Title of Journal: Intensive Care Med

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Abbravation: Intensive Care Medicine

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Springer-Verlag

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DOI

10.1002/chin.199006075

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1432-1238

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Time course of lung injury in rat acute pancreatit

Authors: Denis R Morel JeanLouis Frossard Banu Cikirikcioglu Maxime Tapponnier Catherine M Pastor
Publish Date: 2006/07/15
Volume: 32, Issue: 11, Pages: 1872-1880
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Abstract

Lung injury is a severe complication of acute pancreatitis that increases the mortality rate of the disease The pathophysiology of acute pancreatitis has been studied in several experimental models but the kinetics of pulmonary complications in relation to the pancreatic disease is not completely understood We then studied the severity of acute pancreatitisassociated lung injury over 18 h in rats that had taurocholic acid injection in the pancreatic duct and determined whether blood collected from rats with pancreatitis is toxic enough to induce injury in normal lungsWe isolated lungs from rats with acute pancreatitis 2 6 and 18 h after taurocholic acid injection in the biliopancreatic duct and perfused them with blood collected from the same rats Additionally blood collected from rats with acute pancreatitis timepoints 2 and 6 h was perfused in normal lungsTaurocholic acid injection induced a severe pancreatic injury that started as early as 2 h after the injection and persisted without recovery over the 18h study period In contrast the pulmonary injury was transient appearing at the 6h time point with recovery by the end of the study Pulmonary injury was moderate and evidenced mostly during lung reperfusion Interestingly blood collected at the 2h time point in pancreatic rats induced pulmonary injury in normal lungs while blood collected at the 6h timepoint was not toxicThe electronic reference of this article is http//dxdoiorg/101007/s0013400602649 The online fulltext version of this article includes electronic supplementary material This material is available to authorised users and can be accessed by means of the ESM button beneath the abstract or in the structured fulltext article To cite or link to this article you can use the above reference

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