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Title of Journal: Intensive Care Med

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Abbravation: Intensive Care Medicine

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Springer-Verlag

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DOI

10.1002/gps.3969

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1432-1238

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Effects of lowdose naloxone on opioid therapy in

Authors: C L S Cheung M van Dijk J W Green D Tibboel K J S Anand
Publish Date: 2006/11/07
Volume: 33, Issue: 1, Pages: 190-194
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Abstract

Opioid analgesia and sedative requirements were assessed as morphine and midazolamequivalent doses respectively No differences were observed between groups in opioid doses at baseline or during naloxone but in the postnaloxone period opioid doses tended to be lower in the naloxone group Compared to baseline the naloxone group required more opioids during naloxone but fewer opioids after naloxone Total sedative doses were comparable at baseline in both groups with no differences in the postnaloxone period The naloxone group required less sedation after naloxone but sedation doses were unchanged in controls The two groups did not differ in pain scores sedation scores or opioid side effectsNaloxone did not reduce the need for opioid during the infusion period but tended to reduce opioid requirements in the postnaloxone period without additional need for sedation Randomized clinical trials may examine the effects of lowdose naloxone on opioid tolerance and side effects in pediatric ICU patients requiring prolonged opioid analgesiaThe authors gratefully acknowledge grant support from National Institute for Child Health and Human Development NIH grants U10HD50009 and R01HD36484 to KJSA and ZonMw 94031086 94039004 to DT and the help of JM Tilford PhD for PRISM analyses

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