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Title of Journal: Intensive Care Med

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Abbravation: Intensive Care Medicine

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Springer-Verlag

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DOI

10.1007/1-4020-4364-3

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1432-1238

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The use of propofol for medium and longterm sedat

Authors: Kwok M Ho Joseph Y Ng
Publish Date: 2008/06/25
Volume: 34, Issue: 11, Pages: 1969-
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Abstract

Randomised controlled studies comparing propofol with an alternative sedative agent in critically ill adult patients were included without language restriction from the Cochrane Controlled Trial Register 2007 issue 3 EMBASE and MEDLINE databases 1966 to 1 December 2007 Two reviewers reviewed the quality of the studies and performed data extraction independentlySixteen randomised controlled studies with a total of 1386 critically ill adult patients were considered Nine of the pooled studies 56 limited the doses of propofol infusion to 6 mg/kg h−1 Mortality was not significantly different between patients sedated with propofol or an alternative sedative agent odds ratio OR 105 95 confidence interval CI 080–138 P = 074 I 2  = 0 Using propofol for medium and longterm sedation was associated with a significant reduction in length of ICU stay overall weightedmeandifference WMD in days −099 95CI −151 to −047 P = 00002 I 2 = 8226 when compared to an alternative sedative agent however this benefit became insignificant overall WMD in days −098 95CI −286 to 089 P = 030 I 2 = 788 when the comparison was limited to between propofol and midazolam

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