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Title of Journal: Intensive Care Med

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Abbravation: Intensive Care Medicine

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Springer-Verlag

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DOI

10.1007/1-4020-5093-3_12

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1432-1238

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Protective effect of βglucan on lung injury after

Authors: Hulya Babayigit Can Kucuk Erdogan Sozuer Cevad Yazici Kader Kose Hulya Akgun
Publish Date: 2005/04/08
Volume: 31, Issue: 6, Pages: 865-870
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Abstract

Understanding the biological mediators involved in the complex inflammatory response of sepsis and acute lung injury offers the possibility of future investigations targeting treatment based on these mediators This study investigated whether macrophage activator βglucan has a protective effect on acute lung injury in an experimental model of sepsisRats treated with βglucan had fewer circulating neutrophils more blood monocytes and higher serum interleukin 6 levels than septic animals The percentages of neutrophils and lymphocytes from the bronchoalveolar lavage fluid and the myeloperoxidase activity measured in the lung tissue were lower in the βglucan group than in the sepsis group Less alveolar hemorrhage and neutrophil infiltration were observed in lungs from animals in the βglucan group in the septic groups

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