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Title of Journal: Intensive Care Med

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Abbravation: Intensive Care Medicine

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Springer-Verlag

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DOI

10.1007/s11739-013-0923-0

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1432-1238

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Intracranial pressure

Authors: Giuseppe Citerio Peter J D Andrews
Publish Date: 2004/07/09
Volume: 30, Issue: 10, Pages: 1882-1885
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Abstract

The physiological variables that regulate cerebral blood flow CBF are the factors that influence acute changes in ICP Arterial carbon dioxide gas tension PaCO2 has a near linear relationship with CBF within the physiological range producing a 2–6 increase of CBF for each millimetre of mercury of PaCO2 rise An inverse relationship links low arterial oxygen content and CBFA direct relationship exists between CBF and cerebral metabolic rate for oxygen and glucose CBF is kept constant throughout the normal physiological range of arterial pressure in health These responses are often impaired after acute injury and importantly the lower limit for pressure autoregulation may be

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