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Title of Journal: Intensive Care Med

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Abbravation: Intensive Care Medicine

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Springer-Verlag

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DOI

10.1002/star.19780300908

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1432-1238

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Total brain failure a new contribution by the Pre

Authors: Nereo Zamperetti Rinaldo Bellomo
Publish Date: 2009/04/17
Volume: 35, Issue: 7, Pages: 1305-1307
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Abstract

“Our primary purpose is to define irreversible coma as a new criterion for death” With these words in 1967 the Harvard’s Committee started one of the most influential papers ever published in the medical literature 1 In it the Committee did not produce any scientific reason to justify why braindead patients are dead but used moral and social justifications to demonstrate why they should be regarded as deadIn 1981 a scientific reason was proposed to justify brain death BD with the theory of the “brain as the central integrator of the body” According to this theory after BD the organism becomes a rapidly disintegrating collection of organs Consequently the concept of BD is not a moral and/or social concept and a matter of values but rather a matter of scientific facts an incontrovertible biological datum “Death is the permanent cessation of functioning of the organism as a whole … The criterion of permanent loss of functioning of the entire brain is perfectly

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  1. Higher mean arterial pressure with or without vasoactive agents is associated with increased survival and better neurological outcomes in comatose survivors of cardiac arrest
  2. An international survey of training in adult intensive care medicine
  3. Monitoring brain tissue oxygen tension in brain-injured patients reveals hypoxic episodes in normal-appearing and in peri-focal tissue
  4. The “lung pulse”: an early ultrasound sign of complete atelectasis
  5. Respiratory mechanics in brain-damaged patients
  6. Reporting and handling missing values in clinical studies in intensive care units
  7. Increased ileal-mucosal-arterial PCO 2 gap is associated with impaired villus microcirculation in endotoxic pigs
  8. Increased use of noninvasive ventilation in French intensive care units
  9. Throat and rectal swabs may have an important role in MRSA screening of critically ill patients
  10. The low-dose corticotropin stimulation test in acute traumatic and non-traumatic brain injury: incidence of hypo-responsiveness and relationship to outcome
  11. What were you able to do in your daily life? Performance status for the critically ill patient
  12. Tracheostomy for long-term ventilated patients: a postal survey of ICU practice in The Netherlands
  13. Out-of-hospital interventions by the French Emergency Medical Service are associated with a high survival in patients aged 80 year or over
  14. Myocardial ischaemia and weaning failure: is angioplasty the heart of the problem?
  15. Effect of increasing doses of magnesium in experimental pulmonary hypertension after acute pulmonary embolism
  16. Acute cor pulmonale in ARDS
  17. Putting it all together to predict extubation outcome
  18. The critical importance of symptoms during and after intensive care
  19. Intrapulmonary percussive ventilation superimposed on conventional ventilation: bench study of humidity and ventilator behaviour
  20. Intrapulmonary percussive ventilation superimposed on conventional ventilation: bench study of humidity and ventilator behaviour
  21. The critical importance of symptoms during and after intensive care
  22. Partial extracorporeal lung support in acute respiratory distress syndrome: preliminary experience in a second level hospital
  23. Hemodynamic response to coupled plasmafiltration-adsorption in human septic shock
  24. Did studies on HFOV fail to improve ARDS survival because they did not decrease VILI? On the potential validity of a physiological concept enounced several decades ago
  25. Ultrasound estimation of volume of pleural fluid in mechanically ventilated patients
  26. Intracranial pressure
  27. Hepatic O 2 exchange and liver energy metabolism in hyperdynamic porcine endotoxemia: effects of iloprost
  28. Luxatio cordis due to right pericardium tear, a difficult diagnosis: report of a case
  29. Comparison between cerebral tissue oxygenation index measured by near-infrared spectroscopy and venous jugular bulb saturation in children
  30. Distribution of lung ventilation in spontaneously breathing neonates lying in different body positions
  31. Ionic dialysance: a new valid parameter for quantification of dialysis efficiency in acute renal failure?
  32. The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis
  33. Diagnostic strategy in cancer patients with acute respiratory failure
  34. The impact of inspired oxygen concentration on tissue oxygenation during progressive haemorrhage
  35. Our study 20 years on: a randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients
  36. Macrolide combination antibiotic therapy should be prudently considered in complicated CAP cases and in regions with low macrolide susceptibility
  37. Effect of different seated positions on lung volume and oxygenation in acute respiratory distress syndrome
  38. Planet’s population on the move, infections on the rise
  39. Transpulmonary thermodilution measurements are not affected by continuous veno-venous hemofiltration at high blood pump flow
  40. Delirium in an intensive care unit: a study of risk factors
  41. Feedback and education improve physician compliance in use of lung-protective mechanical ventilation
  42. Authors' reply to the comment by Kox et al.
  43. Cytokeratin 19 fragments in patients with acute lung injury: a preliminary observation
  44. Current management and outcome of tracheobronchial malacia and stenosis presenting to the paediatric intensive care unit
  45. Current management and outcome of tracheobronchial malacia and stenosis presenting to the paediatric intensive care unit
  46. Dynamic predictors of VILI risk: beyond the driving pressure
  47. Energy deficit is clinically relevant for critically ill patients: yes
  48. The epidemiology of acute respiratory distress syndrome in pediatric intensive care units in China
  49. Pattern of end-of-life decisions in two Tunisian intensive care units: the role of culture and intensivists’ training
  50. Patient safety in intensive care medicine: the Declaration of Vienna
  51. Time course of lung injury in rat acute pancreatitis
  52. If antibiotics did not exist
  53. A randomised controlled trial investigating the effects of dopexamine on gastrointestinal function and organ dysfunction in the critically ill
  54. Cardiac biochemical monitoring for the detection of acute myocardial ischemia
  55. Effects of low-dose naloxone on opioid therapy in pediatric patients: a retrospective case-control study
  56. Ten reasons to be more attentive to patients when setting the ventilator
  57. Factors associated with increased risk of readmission to intensive care in Australia
  58. Teaching difficult airway management: is virtual reality real enough?
  59. Milrinone for cardiac dysfunction in critically ill adult patients: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
  60. Impact of multifaceted preventive measures on ventilator-associated pneumonia at a single surgical centre
  61. Air embolism in the internal jugular vein
  62. Negative randomized clinical trials (RCTs): further insight from the biostatistician’s point of view
  63. A survey on patients admitted in severe coma: implications for brain death identification and organ donation
  64. Non-invasive radiation-free monitoring of regional lung ventilation in critically ill infants
  65. Is sedation safe and beneficial in patients receiving NIV? No
  66. Pulse oximetry and high-dose vasopressors: a comparison between forehead reflectance and finger transmission sensors
  67. Apocynin attenuates ventilator-induced lung injury in an isolated and perfused rat lung model
  68. Reply to Gibot
  69. Debriefing to improve outcomes from critical illness: a systematic review and meta-analysis
  70. Systematic review and evaluation of physiological track and trigger warning systems for identifying at-risk patients on the ward
  71. Oxygen, temperature and humidity of inspired gases and their influences on airway and lung tissue in near-term lambs
  72. More interventions do not necessarily improve outcome in critically ill patients
  73. High values of the pulmonary artery wedge pressure in patients with acute lung injury and acute respiratory distress syndrome
  74. Admission blood glucose is an independent predictive factor for hospital mortality in polytraumatised patients
  75. Time to reach a new equilibrium after changes in PEEP in acute respiratory distress syndrome patients
  76. The “open lung” compromise
  77. Protective effect of β-glucan on lung injury after cecal ligation and puncture in rats
  78. Brain energy metabolism during controlled reduction of cerebral perfusion pressure in severe head injuries
  79. Comments on Baranwal et al: Dexamethasone pretreatment for 24 h versus 6 h for prevention of postextubation airway obstruction in children
  80. Sonographic diagnosis of pneumothorax
  81. Is right ventricular function the one that matters in ARDS patients? Definitely yes
  82. Determinants of time to death in hospital in critically ill patients around the world
  83. Cognitive and perceived health status in patient with chronic obstructive pulmonary disease surviving acute on chronic respiratory failure: a controlled study
  84. Left ventricular dysfunction in lethal severe brain injury: impact of transesophageal echocardiography on patient management
  85. Weight-for-age distribution and case-mix adjusted outcomes of 14,307 paediatric intensive care admissions
  86. Weight-for-age distribution and case-mix adjusted outcomes of 14,307 paediatric intensive care admissions
  87. Platelet and soluble CD40L in meningococcal sepsis
  88. Management of ventilator-associated pneumonia in a multidisciplinary intensive care unit: does trauma make a difference?
  89. High-flow nasal cannula oxygen during endotracheal intubation in hypoxemic patients: a randomized controlled clinical trial
  90. Prospects for acute stroke— what can intensive care medicine offer?
  91. Pharmacokinetics of oseltamivir carboxylate in critically ill patients: each patient is unique
  92. Serum levels of gastric-acid-stimulating factors in children undergoing open heart surgery
  93. Weaning failure from cardiovascular origin
  94. Sequential changes in compliance and resistance after bolus administration or slow infusion of surfactant in preterm infants
  95. Discrepancies between observed and predicted continuous venovenous hemofiltration removal of antimicrobial agents in critically ill patients and the effects on dosing
  96. What’s new in ARDS: can we prevent it?
  97. Clinical identification of cognitive impairment in ICU survivors: insights for intensivists
  98. Efficacy and safety of regional citrate anticoagulation in critically ill patients undergoing continuous renal replacement therapy
  99. Swallowing disorders post orotracheal intubation in the elderly
  100. Tracheal double-lumen ventilation attenuates hypercapnia and respiratory acidosis in lung injured pigs
  101. Passive leg raising for predicting fluid responsiveness: importance of the postural change
  102. Association of prior antiplatelet agents with mortality in sepsis patients: a nationwide population-based cohort study
  103. Small dead space heat and moisture exchangers do not impede gas exchange during noninvasive ventilation: a comparison with a heated humidifier
  104. The use of propofol for medium and long-term sedation in critically ill adult patients: a meta-analysis
  105. Association of prior antiplatelet agents with mortality in sepsis patients: a nationwide population-based cohort study
  106. High-frequency oscillatory ventilation in experimental lung injury: effects on gas exchange
  107. Suctioning through a double-lumen endotracheal tube helps to prevent alveolar collapse and to preserve ventilation
  108. What is the optimal post-arrest hemodynamic strategy? Towards personalized resuscitation strategies
  109. Pharmacokinetic/pharmacodynamic analysis of vancomycin in ICU patients
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