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Title of Journal: Intensive Care Med

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Abbravation: Intensive Care Medicine

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Springer-Verlag

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1432-1238

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Respiratory mechanics in braindamaged patients

Authors: Antonia Koutsoukou Helen Perraki Asimina Raftopoulou Nikolaos Koulouris Christina Sotiropoulou Anastasia Kotanidou Stylianos Orfanos Charis Roussos
Publish Date: 2006/10/20
Volume: 32, Issue: 12, Pages: 1947-1954
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Abstract

Twentyone consecutive mechanically ventilated patients with severe brain damage and no acute lung injury were randomly assigned to be ventilated with ZEEP n = 10 or with 8 cmH2O of PEEP n = 11 Respiratory mechanics and arterial blood gases were assessed on days 1 and day 5 of mechanical ventilationIn the ZEEP group on day 1 static elastance and minimal resistance were above normal limits 189 ± 38 cmH2O/l and 56 ± 22 cmH2O/l per second respectively on day 5 static elastance and isoCO2 minimal resistance values were higher than on day 1 212 ± 41 cmH2O/l 70 ± 19 cmH2O/l per second respectively In the PEEP group these parameters did not change significantly One of the ten patients on ZEEP developed acute lung injury On day 5 there was a significant decrease in PaO2/FIO2 in both groupsOn day 1 of mechanical ventilation patients with brain damage exhibit abnormal respiratory mechanics After 5 days of mechanical ventilation on ZEEP static elastance and minimal resistance increased significantly perhaps reflecting “low lung volume” injury Both could be prevented by administration of moderate levels of PEEP

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