Authors: J H Jaster H B Niell F C Dohan T W Smith
Publish Date: 2003/09/05
Volume: 82, Issue: 11, Pages: 714-715
Abstract
We read with interest the report of Tomonari et al 1 describing a 48yearold woman who experienced acute disseminated encephalomyelitis ADEM following bone marrow transplantation for acute myeloid leukemia AML Her diagnosis of AML in June 1999 was followed by bone marrow transplantation BMT in January 2000 Neurologic symptoms began in October 2000 and multifocal cerebral white matter abnormalities were observed on magnetic resonance imaging 2 weeks later while testing of peripheral blood and cerebrospinal fluid revealed no pertinent abnormalities Brain imaging and other laboratory data together with the patients clinical course supported the diagnosis of ADEMIn their discussion the authors assert that transplantation and/or attendant immunosuppression may have been the etiology of ADEM in their case The authors emphasize the rare occurrence of ADEM in the setting of transplantation and immunosuppression and they are able to cite only a few cases of ADEM in similar
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