Authors: Rekha Athiyarath Biju George Vikram Mathews Alok Srivastava Eunice S Edison
Publish Date: 2014/05/28
Volume: 93, Issue: 12, Pages: 2093-2095
Abstract
The rate of iron absorption is influenced by the size of body iron stores the level of erythropoietic activity in the bone marrow the hemoglobin concentration the oxygen content in the circulation and the presence of inflammation 1 β Thalassemia is a monogenic disease in which defective globin synthesis results in ineffective erythropoiesis and anemia resulting in iron overload Transfusions remain the major stay of treatment for βthalassemia There is little understanding of the interindividual variation observed in transfusionacquired iron overload and the molecular events that occur during transfusional iron overload Hepcidin synthesis is stimulated by iron overload and inflammation while erythropoietic activity decreases its production 2 3 Growth differentiation factor15 GDF15 a member of TGFβ super family has been reported to mediate the suppression of hepcidin in thalassemia 4 Polymorphisms in GDF15 and increased expression have beenThis study was supported by a grant BT/PR13968/MED/12/465/2010 from the Department of Biotechnology Government of India to ES RA is supported by senior research fellowship from CSIR India We also thank Dr Jude J Fleming Professor Department of Clinical Biochemistry for his critical review of the manuscript
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