Authors: Soon Thye Lim Nancy Rubin Jonathan Said Alexandra M Levine
Publish Date: 2005/03/31
Volume: 84, Issue: 8, Pages: 551-552
Abstract
A 45yearold homosexual male was first treated for HIV infection in 1992 with stavudine and didanosine In 1998 he presented with abdominal pain Colonoscopy revealed a large tumor mass in the transverse colon histologically diagnosed as diffuse large Bcell lymphoma which was negative for CD20 CD30 and CD3 There were no other sites of disease involvement and he received cyclophosphamide adriamycin vincristine and prednisone CHOP However he developed paralytic ileus after the first cycle and etoposide was substituted for vincristine Six cycles of chemotherapy were administered resulting in complete remission CR of disease The patient chose to discontinue antiretroviral therapy in late 2000Three years later he presented with a large pericardial effusion Urgent pericardiocentesis was performed and 700 ml of fluid was removed Cytological examination and immunophenotypic analysis of the pericardial fluid showed the presence of large “blastlike” CD20 negative tumor
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