Authors: Yin Key Lai Nai Ming Lai Shaun Wen Huey Lee
Publish Date: 2017/02/14
Volume: 96, Issue: 5, Pages: 839-845
Abstract
Emerging epidemiological evidence suggests that patients with glucose6phosphate dehydrogenase G6PD deficiency may have a higher risk of developing diabetes The aim of the review was to synthesise the evidence on the association between G6PD deficiency and diabetes A systematic search on Medline EMBASE AMED and CENTRAL databases for studies published between January 1966 and September 2016 that assessed the association between G6PD deficiency and diabetes was conducted This was supplemented by a review of the reference list of retrieved articles We extracted data on study characteristics outcomes and performed an assessment on the methodological quality of the studies A randomeffects model was used to compute the summary risk estimates Fifteen relevant publications involving 949260 participants were identified from which seven studies contributed to the metaanalysis G6PD deficiency was associated with a higher odd of diabetes odds ratio 237 95 confidence interval 150–373 The odds ratio of diabetes among men was higher 222 131–375 compared to women 187 112–312 This association was broadly consistent in the sensitivity analysis Current evidence suggests that G6PD deficiency may be a risk factor for diabetes with higher odds among men compared to women Further research is needed to determine how G6PD deficiency moderates diabetesSWHL NML and YKL undertook the literature search and reviewed the abstracts and full articles SWHL conceived the idea drafted the initial manuscript and performed the statistical analysis All authors designed the study contributed to the discussion and critically reviewed the final manuscript
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