Authors: Ulrike Bacher Torsten Haferlach Wolfgang Kern Wolfgang Hiddemann Susanne Schnittger Claudia Schoch
Publish Date: 2005/02/04
Volume: 84, Issue: 4, Pages: 250-257
Abstract
In chronic myeloproliferative disorders other than CML CMPD recurrent cytogenetic abnormalities occur but specific patterns of chromosomal aberrations in the specific entities have so far not been detected Thus the value of conventional cytogenetics in the routine diagnostic setting of CMPD remains to be clarified We performed a cytogenetic study on 409 patients with different CMPD polycythemia vera essential thrombocytosis ET idiopathic osteomyelofibrosis chronic myelomonocytic leukemia proliferative subtype idiopathic hypereosinophilic syndrome HES myeloproliferative syndrome unclassifiable and on 102 patients with suspected CMPD Cytogenetic abnormalities occurred in different frequencies ranging from 3 to 40 depending on the subtype and showed some specific differences with respect to their type The highest frequency and the most complex pattern of clonal aberrations were observed in idiopathic osteomyelofibrosis However clonal aberrations were also found in 10 of patients with suspected CMPD establishing the diagnosis of a malignant disease In conclusion cytogenetics are essential in the routine diagnostic setting of CMPD or cases suspicious for CMPD In ET and in HES the aberration rate was only 3 and 7 respectively Thus cytogenetics can be omitted However in some of these cases molecular procedures should be integrated into the routine diagnostic process
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