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Title of Journal: Ann Hematol

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Abbravation: Annals of Hematology

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Springer Berlin Heidelberg

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DOI

10.1002/anie.197602381

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1432-0584

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Diffuse large Bcell lymphoma arising from donor l

Authors: M T Cibeira A LopezGuillermo D Colomer M J Ricart A Alcaraz A Martinez E Campo E Montserrat
Publish Date: 2003/02/11
Volume: 82, Issue: 2, Pages: 131-135
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Abstract

A patient with both a renal and pancreatic transplantation developed a diffuse large Bcell lymphoma EpsteinBarr virusrelated 14 months after the surgical procedure Tumor was confined to the transplanted organs head of the pancreas and hilar lymph node of the transplanted kidney Chimerism analysis demonstrated the tumor origin from donor lymphoid cells Immunosuppression was discontinued and chemotherapy with cyclophosphamide hydroxydaunomycin vincristine and prednisone CHOP was started However no response was observed after three courses of this regimen Finally a transplantectomy was carried out followed by rituximab antiCD20 antibody with the patient achieving a complete response CR Two years later the patient remains in CR

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