Authors: Makoto Hirosawa Takehiro Higashi Atsushi Iwashige Takahiro Yamaguchi Junichi Tsukada
Publish Date: 2016/10/21
Volume: 96, Issue: 2, Pages: 327-328
Abstract
Allogeneic hematopoietic stem cell transplantation alloHSCT has been considered as standard therapy for aggressive adult T cell leukemia/lymphoma ATLL patients to achieve a longterm survival 1 2 AntiCCR4 monoclonal antibody mogamulizumab Mog is the first immunotherapeutic agent targeting ATLL Since CCR4 is expressed on regulatory T cells Treg there is growing concern regarding increased risk of severe and refractory acute graftversushost disease aGVHD in ATLL patients treated with Mog before alloHSCT pretransplant Mog 3 4 5 6
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