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Title of Journal: Ann Hematol

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Abbravation: Annals of Hematology

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Springer Berlin Heidelberg

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DOI

10.1006/jmbi.2001.4637

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ISSN

1432-0584

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Prognostic significance of IKZF1 deletion in adult

Authors: Wanhua Zhang Pu Kuang He Li Fengjuan Wang Yu Wang
Publish Date: 2016/11/04
Volume: 96, Issue: 2, Pages: 215-225
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Abstract

The IKAROS family zinc finger 1 IKZF1 gene is frequently altered in adults with B cell acute lymphoblastic leukemia ALL Although many studies have indicated that IKZF1 alterations might be associated with poor outcomes in adults with ALL the results remain controversial A previous metaanalysis demonstrated the negative prognostic significance of IKZF1 deletion in ALL However most of the included studies 14 out of 15 were conducted in pediatric patients with ALL and age was identified as a significant source of heterogeneity Thus performing the present metaanalysis provides valuable information to further elucidate the prognostic value of IKZF1 deletion in adults with ALL Eight studies were identified that had been published prior to August 1 2016 The studies included a total of 1008 patients Hazard ratios HRs with 95 confidence intervals CIs of overall survival OS and diseasefree survival DFS/relapsefree survival RFS/progressionfree survival PFS/eventfree survival EFS were pooled to estimate the prognostic power of IKZF1 deletion Pooled HRs suggested that IKZF1 deletion had a negative impact on both OS HR = 140 95 CI 113–173 and DFS/RFS/PFS/EFS HR = 167 95 CI 128–217 in the overall population Subgroup analyses indicated that IKZF1 deletion could independently predict unfavorable OS HR = 160 95 CI 125–206 and DFS/RFS/PFS/EFS HR = 167 95 CI 128–217 in BCRABL1negative but not in BCRABL1positive B cell ALL patients Our metaanalysis suggests that IKZF1 deletion is a poor prognostic factor for adults with B cell ALL and may be more valuable in BCRABL1negative B cell ALL patients

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