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Title of Journal: Ann Hematol

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Abbravation: Annals of Hematology

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Springer-Verlag

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DOI

10.1016/0378-4363(81)90402-2

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1432-0584

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A systematic review and metaanalysis of rituximab

Authors: Cheng Fang Wei Xu JianYong Li
Publish Date: 2010/05/25
Volume: 89, Issue: 11, Pages: 1107-1113
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Abstract

Addition of rituximab to chemotherapy Rchemo has been shown to improve overall survival OS in patients with diffuse large B cell lymphoma DLBCL Germinal center B celllike GCB subtype of DLBCL has a significantly better clinical outcome than those with nongerminal center B celllike nonGCB subtype Further research is needed to confirm this difference between those two subtypes treated with Rchemo We searched for randomized controlled trials that compared Rchemo with identical chemotherapy alone in patients with newly diagnosed or relapsed DLBCL A random versus fixed effects model was selected according to heterogeneity Six eligible trials involving 748 adult patients were included in this metaanalysis Fixedeffects analysis showed OS to be superior for the GCB patients treated with Rchemo relative risk RR = 116 95 confidence interval CI = 103–131 P = 002 Superiority was also observed for the GCB subtype under Rchemo with respect to disease control RR = 116 95 CI = 099–136 and overall response RR = 119 95 CI = 099–199 Both subtypes showed an increased OS RR = 130 95 CI = 111–151 RR = 189 95 CI = 152–235 respectively and disease control rate RR = 127 95 CI = 105–154 P = 001 RR = 221 95 CI = 168–290 respectively following Rchemo Therefore treated with Rchemo GCB patients still has a significantly better clinical outcome than those with nonGCB subtype

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