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Title of Journal: Ann Hematol

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Abbravation: Annals of Hematology

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Springer-Verlag

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DOI

10.1002/prac.19753170620

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1432-0584

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Constitutional pericentric inversion of chromosome

Authors: K N Manola N Harhalakis A Symeonidis H Rigana C Stavropoulou D Karakasis M Tiniakou I Baltathakis M I Stamouli N Zoumbos G E Pantelias C Sambani
Publish Date: 2006/06/07
Volume: 85, Issue: 9, Pages: 611-615
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Abstract

Recent reports suggest that hemopoietic stem cells with constitutional pericentric inversion of chromosome 9 inv9 may be related to delayed engraftment or hemopoietic defect after stem cell transplantation SCT We conducted a retrospective study on five allogeneic SCT in which constitutional inv9 was detected either in the donor or the recipient The results showed that hematologic recovery was within the expected time range for all our patients However one patient exhibited decreasing blood counts between day +45 and +272 after transplantation possibly due to protracted cytomegalovirus CMV infection and gansiclovir and imatinib treatment Our findings suggest that constitutional inv9 may not be associated with delayed hemopoietic recovery after SCT

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