Authors: Su Kyung Jung Ji Sun Paik SeungEun Jung Gyeongsin Park ByungOck Choi Jin Kyoung Oh Yong Gyu Park Suk Woo Yang SeokGoo Cho
Publish Date: 2015/03/03
Volume: 94, Issue: 7, Pages: 1185-1193
Abstract
Ocular adnexal mucosaassociated lymphoid tissue lymphoma OAML has been recognized as most common primary orbital malignancy However little was known about the response criteria for OAML Our aim was to suggest response criteria for nonconjunctival OAML the response evaluation of which using the conventional response criteria is inappropriate A retrospective chart review of 34 eyes from 30 patients diagnosed with nonconjunctival OAML was conducted focusing on the change in tumor size based on linear bidimensional and threedimensional methods in magnetic resonance imaging MRI of the orbit The maximum tumor response period of each case was investigated and the expected optimal response period was calculated using regression analysis In 30 evaluable patients the median time taken for the maximum tumor response was 6 months range 3–18 More than 75 of patients attained maximal tumor response in 6 months after initial therapy for followup period the median value of which was 30 months range 15–77 Based on the regression analysis it took 47 months for the maximum diameter 2r of tumor to decrease by 50 of initial lesion size We cautiously suggest that optimal response could be defined as 50 reduction of the maximum diameter in 6 months since the treatment was initiated and that only observation without additional therapy is enough for nonconjunctival OAML if optimal response is achieved
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