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Title of Journal: Ann Hematol

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Abbravation: Annals of Hematology

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Springer-Verlag

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1432-0584

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Ciprofloxacin inhibits lipopolysaccharideinduced

Authors: Masami Kaji Junji Tanaka Junichi Sugita Naoko Kato Makoto Ibata Yusuke Shono Shuichi Ohta Takeshi Kondo Masahiro Asaka Masahiro Imamura
Publish Date: 2007/08/28
Volume: 87, Issue: 3, Pages: 229-231
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Abstract

Lipopolysaccharide LPS interacts with immune cells by binding to CD14 molecules and then interacts with tolllike receptor TLR4 on monocytes and dendritic cells 1 2 3 On the other hand TLR8 recognizes viral singlestranded RNA ssRNA 4 Therefore TLR4 is involved in immunological events during bacterial infection and TLR8 is involved in immunological events during viral infection Ciprofloxacin CIP a fluorinated 4quinolone is one of the quinolone antibiotics CIP reduces the population of intestinal bacteria and influences the development of acute graftvshost disease GVHD after allogeneic bone marrow transplantation for hematological malignancies 5 In addition CIP has modulatory actions on immune and inflammatory responses such as inhibition of the production of tumor necrosis factor TNFα in LPSstimulated peripheral blood mononuclear cells PBMC 6 The mechanisms underlying the effects of quinolones on immune modulation might depend on

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  2. Prophylactic intravenous immunoglobulin during autologous haemopoietic stem cell transplantation for multiple myeloma is not associated with reduced infectious complications
  3. Risk factors for poor treatment outcome and central nervous system relapse in diffuse large B-cell lymphoma with bone marrow involvement
  4. A systematic review and meta-analysis of rituximab-based immunochemotherapy for subtypes of diffuse large B cell lymphoma
  5. Therapeutic implication of BAL in patients with neutropenia
  6. Effect of altered iron metabolism on markers of haem biosynthesis and intestinal iron absorption in mice
  7. Glucose-6-phosphate dehydrogenase deficiency and risk of diabetes: a systematic review and meta-analysis
  8. Patients with diffuse large B cell lymphoma in partial response or stable disease after first-line R-CHOP: the prognostic value of the absolute lymphocyte count and impact of autologous stem cell transplantation
  9. Lung injury in a leukemia patient during mobilization of peripheral blood stem cells using granulocyte colony-stimulating factor alone
  10. Primary MALT lymphoma of the urinary bladder in the background of interstitial cystitis
  11. Clinical and biological impact of TET2 mutations and expression in younger adult AML patients treated within the EORTC/GIMEMA AML-12 clinical trial
  12. Epidemiological profile of hemoglobinopathies in the Mauritanian population
  13. Efficacy and safety of deferasirox in myelodysplastic syndromes
  14. Haemoglobin Hokusetsu [β52 (D3)] Asp→Gly in German families associated with inclusion body
  15. Suggestion of response evaluation criteria in patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML)
  16. Porcine antilymphocyte globulin (p-ALG) plus cyclosporine A (CsA) treatment in acquired severe aplastic anemia: a retrospective multicenter analysis
  17. Is the quantity of circulatory cell-free DNA in human plasma and serum samples associated with gender, age and frequency of blood donations?
  18. Searching for antigen epitope specificities in the monoclonal IgG molecules of patients with multiple myeloma. The description of a monoclonal antibody with a dynein-specific antigen epitope character
  19. A de novo ankyrin mutation (ANK1 Q109X) causing severe hereditary spherocytosis from preterm neonatal period
  20. Reusable terminal tap water filters for nosocomial legionellosis prevention
  21. Association between low uric acid levels and acute graft-versus-host disease
  22. Treatment with monoclonal antibodies in acute lymphoblastic leukemia: current knowledge and future prospects
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  24. Outcome of treatment in adults with Philadelphia chromosome-positive and/or BCR–ABL-positive acute lymphoblastic leukemia—retrospective analysis of Polish Adult Leukemia Group (PALG)
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  26. Primary effusion lymphoma: successful treatment with highly active antiretroviral therapy and rituximab
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  28. Perioperative management of a patient with Fechtner syndrome
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  30. Long-term results of autologous stem cell transplantation for Hodgkin’s disease (HD) and low-/intermediate-grade B non-Hodgkin’s lymphoma (NHL): a report from the Austrian Stem Cell Transplantation Registry (ASCTR)
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  40. Rituximab retherapy in patients with relapsed aggressive B cell and mantle cell lymphoma
  41. Economic evaluation of caspofungin vs liposomal amphotericin B for empirical therapy of suspected systemic fungal infection in the German hospital setting
  42. Maximum standard uptake value of 18 F-fluorodeoxyglucose positron emission tomography is a prognostic factor for progression-free survival of newly diagnosed patients with diffuse large B cell lymphoma
  43. Diffuse large B-cell lymphoma arising from donor lymphoid cells after renal and pancreatic transplantation
  44. FLT3 -ITD and MLL -PTD influence the expression of MDR-1 , MRP-1 , and BCRP mRNA but not LRP mRNA assessed with RQ-PCR method in adult acute myeloid leukemia
  45. Replacement of conventional doxorubicin by pegylated liposomal doxorubicin is a safe and effective alternative in the treatment of non-Hodgkin's lymphoma patients with cardiac risk factors
  46. Azacitidine in 302 patients with WHO-defined acute myeloid leukemia: results from the Austrian Azacitidine Registry of the AGMT-Study Group
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  49. Suboptimal doses of low molecular weight heparin and acute venous thromboembolism. Data from the RIETE registry
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  52. Combined thalidomide and cyclophosphamide treatment for refractory or relapsed multiple myeloma patients: a prospective phase II study
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  55. Perceived information provision and satisfaction among lymphoma and multiple myeloma survivors—results from a Dutch population-based study
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