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Title of Journal: Ann Hematol

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Abbravation: Annals of Hematology

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Springer-Verlag

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10.1016/0040-4039(95)00253-9

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1432-0584

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Hematologic malignancies with Emphasis Type="Ital

Authors: Verena Patterer Susanne Schnittger Wolfgang Kern Torsten Haferlach Claudia Haferlach
Publish Date: 2013/02/12
Volume: 92, Issue: 6, Pages: 759-769
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Abstract

The translocation t89p22p24 is a rare event that results in the fusion of JAK2 to PCM1 and thus leads to the activation of the Janus Kinase 2 In 2008 the WHO introduced a new entity called “Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA PDGFRB or FGFR1” which are characterized by the formation of a fusion gene encoding an aberrant tyrosine kinase These disorders share characteristics with myeloproliferative neoplasms and typically show an eosinophilia We here now report on 6 new cases with PCM1JAK2 fusion These patients show characteristics with respect to epidemiology clinical presentation and genetic changes that are very similar to patients with rearrangements of PDGFRA PDGFRB or FGFR1 Our data suggests the integration of cases with JAK2PCM1 fusion in the respective WHO category of myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA PDGFRB or FGFR1

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