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Title of Journal: Breast Cancer Res Treat

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Abbravation: Breast Cancer Research and Treatment

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Springer US

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DOI

10.1016/j.appet.2015.03.034

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1573-7217

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Cytosolic levels of TFF1/pS2 in breast cancer the

Authors: Maria D Corte Francisco Tamargo Ana Alvarez JC Rodríguez J Vázquez Rosario Sánchez Maria L Lamelas LO González Maria T Allende JL GarcíaMuñiz A Fueyo F Vizoso
Publish Date: 2005/11/03
Volume: 96, Issue: 1, Pages: 63-72
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Abstract

The Trefoil Factor 1 TFF1/pS2 a peptide consisting of 60 amino acids is the most abundant estrogeninduced messenger RNA present in MCF7 breast cancer cells The objective of this work was to evaluate the cytosolic TFF1 content in breast carcinomas its possible relationship with different clinical–pathological parameters and its potential prognostic significance and predictive valueThere was a wide variability of cytosolic TFF1 levels in tumors 09–7432 ng/mg protein Statistical analysis showed that TFF1 levels were significantly higher in premenopausal patients p=0001 as well as in tumors showing any of the following characteristics good differentiation p=00001 ER and PgR positivity p=00001 and p=0001 respectively diploidy p=0045 and a high Sphase fraction p=0001 In addition the presence of high intratumoral TFF1 levels cutoff 2 ng/mg protein was independently associated with a shorter overall survival in the group of patients as a whole p=0001 as well as in the subgroup with nodenegative breast cancer p=00004 Likewise high intratumoral TFF1 levels were associated with a more prolonged overall survival in patients who received adjuvant tamoxifen p=0004In breast cancer patients intratumoral TFF1 levels are associated with a better clinical outcome especially in those with nodenegative tumors In addition TFF1 levels have a low but significant predictive value in regards to response to adjuvant therapy with tamoxifen

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