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Title of Journal: Breast Cancer Res Treat

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Abbravation: Breast Cancer Research and Treatment

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Springer US

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DOI

10.1007/s11120-004-6555-5

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ISSN

1573-7217

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XRCC2 Arg188His polymorphism is not directly assoc

Authors: KeDa Yu AoXiang Chen LiXin Qiu Lei Fan Chen Yang ZhiMing Shao
Publish Date: 2010/02/02
Volume: 123, Issue: 1, Pages: 219-225
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Abstract

Several common singlenucleotide polymorphisms SNPs within the XRCC2 gene have been identified as potential breast cancer susceptibility loci and a coding SNP in exon 3 Arg188His rs3218536 has been extensively studied though the results were inconclusive We in this study performed a more convincing and precise estimation of the relationship between Arg188His and breast cancer by metaanalyzing the currently available evidence from literature A total of 16 studies involving 18341 cases and 19028 controls 37369 subjects were identified for metaanalysis Crude odds ratios ORs with 95 confidence intervals CIs were used to assess the strength of association in the codominant model dominant model and recessive model When all the studies were pooled into metaanalysis there was no evidence of a significant association between Arg188His and breast cancer risk in any genetic models Notably Arg188His tended to be related to breast cancer in a fixedeffects dominant model OR = 0922 95 CI 0870–0978 P = 0007 however since there was a betweenstudy heterogeneity P h = 0014 we assessed the association using a randomeffects model instead and no significance was observed OR = 0932 95 CI 0852–1020 P = 0128 Subgroup analysis by ethnicity did not change the results In summary the present metaanalysis suggests that the XRCC2 Arg188His is not directly associated with breast cancer risk However considering that susceptibility is likely to be the result of a complex interplay between genetic variation and environmental factors we cannot rule out the possibility of interactions between Arg188His and other variants Further investigation on the influence of this SNP in modifying the relationship between environment exposures and breast cancer risk is still needed

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